Protein-losing gastroenteropathy in a patient with concomitant systemic lupus erythematosus and Sjögren’s syndrome
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- Mizuna Eguchi
- Department of General and Internal Medicine, National Hospital Organization Nagasaki Medical Center, Omura, Nagasaki, Japan;
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- Nozomi Iwanaga
- Department of General and Internal Medicine, National Hospital Organization Nagasaki Medical Center, Omura, Nagasaki, Japan;
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- Kosuke Sakai
- Department of General and Internal Medicine, National Hospital Organization Nagasaki Medical Center, Omura, Nagasaki, Japan;
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- Tohru Michitsuji
- Department of General and Internal Medicine, National Hospital Organization Nagasaki Medical Center, Omura, Nagasaki, Japan;
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- Yoshika Tsuji
- Department of General and Internal Medicine, National Hospital Organization Nagasaki Medical Center, Omura, Nagasaki, Japan;
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- Chieko Kawahara
- Department of General and Internal Medicine, National Hospital Organization Nagasaki Medical Center, Omura, Nagasaki, Japan;
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- Hitomi Kobayashi
- Department of Gastroenterology, National Hospital Organization Nagasaki Medical Center, Omura, Nagasaki, Japan;
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- Yoshiro Horai
- Department of General and Internal Medicine, National Hospital Organization Nagasaki Medical Center, Omura, Nagasaki, Japan;
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- Takahiro Mori
- Department of General and Internal Medicine, National Hospital Organization Nagasaki Medical Center, Omura, Nagasaki, Japan;
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- Yasumori Izumi
- Department of General and Internal Medicine, National Hospital Organization Nagasaki Medical Center, Omura, Nagasaki, Japan;
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- Masahiro Ito
- Clinical Research Center, National Hospital Organization Nagasaki Medical Center, Omura, Nagasaki, Japan;
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- Atsushi Kawakami
- Division of Advanced Preventive Medical Sciences, Department of Immunology and Rheumatology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan
説明
We report a female in her twenties who developed generalized edema. She was diagnosed as systemic lupus erythematous (SLE) and Sjögren's syndrome (SS) based on her physical manifestations and positive findings for antinuclear antibody and anti-SS-A/SS-B-antibody. Although she manifested hypoproteinemia, a possibility of lupus nephritis was denied due to a lack of significant abnormality in kidney function tests and urinalysis. The nature of hypoproteinemia and related symptoms was identified as protein losing gastroenteropathy (PLGE) based on α 1-antitrypsin clearance and histopathology findings. Physicians should be aware that PLGE may develop as an underlying cause of edema in SLE and SS.
収録刊行物
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- Immunological Medicine
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Immunological Medicine 41 (1), 34-38, 2018-01-02
Informa UK Limited