PhotonSABER: new tool shedding light on endocytosis and learning mechanisms <i>in vivo</i>

  • Shinji Matsuda
    Department of Physiology, Keio University School of Medicine, Tokyo, Japan
  • Wataru Kakegawa
    Department of Physiology, Keio University School of Medicine, Tokyo, Japan
  • Michisuke Yuzaki
    Department of Physiology, Keio University School of Medicine, Tokyo, Japan

Description

In the central nervous system, activity-dependent endocytosis of postsynaptic AMPA-type glutamate receptors (AMPA receptors) is thought to mediate long-term depression (LTD), which is a synaptic plasticity model in various neuronal circuits. However, whether and how AMPA receptor endocytosis and LTD at specific synapses are causally linked to learning and memory

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