Serial measurements of KL-6 for monitoring activity and recurrence of interstitial pneumonia with anti-aminoacyl-tRNA synthetase antibody
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- Kakuhiro Yamaguchi
- Department of Molecular and Internal Medicine
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- Hiroshi Iwamoto
- Department of Molecular and Internal Medicine
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- Shinjiro Sakamoto
- Department of Molecular and Internal Medicine
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- Yasushi Horimasu
- Department of Molecular and Internal Medicine
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- Takeshi Masuda
- Department of Molecular and Internal Medicine
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- Shintaro Miyamoto
- Department of Molecular and Internal Medicine
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- Taku Nakashima
- Department of Molecular and Internal Medicine
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- Shinichiro Ohshimo
- Department of Emergency and Critical Care Medicine
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- Kazunori Fujitaka
- Department of Molecular and Internal Medicine
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- Hironobu Hamada
- Department of Physical Analysis and Therapeutic Sciences, Graduate School of Biomedical and Health Sciences, Hiroshima University
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- Nobuoki Kohno
- Hiroshima Cosmopolitan University, Hiroshima, Japan.
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- Noboru Hattori
- Department of Molecular and Internal Medicine
Bibliographic Information
- Other Title
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- A retrospective cohort study
Description
<jats:sec> <jats:title>Abstract</jats:title> <jats:p>The aim of this study was to evaluate whether serial measurements of serum Krebs von den Lungen-6 (KL-6) could be used to monitor disease activity and to detect recurrence in patients with interstitial pneumonia (IP) with anti-aminoacyl-tRNA synthetase antibodies (ARS-IP).</jats:p> <jats:p>This retrospective cohort study included 44 patients with ARS-IP. Thirty-six patients had serial data of blood tests and pulmonary function tests. Baseline and longitudinal analyses were performed to investigate whether lung function parameters were associated with serum biomarkers (KL-6, lactate dehydrogenase [LDH], and C-reactive protein [CRP]) using Pearson correlation coefficient. Additionally, the diagnostic accuracy of changes in these biomarkers for detecting ARS-IP recurrence was analyzed by receiver operating characteristic curve analysis.</jats:p> <jats:p>Baseline levels of serum KL-6 were significantly associated with vital capacity (VC) and diffusion capacity for carbon monoxide (DLco) (<jats:italic toggle="yes">r</jats:italic> = −0.40, <jats:italic toggle="yes">P</jats:italic> = .015, and <jats:italic toggle="yes">r</jats:italic> = −0.44, <jats:italic toggle="yes">P</jats:italic> = .010, respectively). Longitudinal changes in KL-6 were inversely correlated with changes in VC and DLco (<jats:italic toggle="yes">r</jats:italic> = −0.57, <jats:italic toggle="yes">P</jats:italic> <.001 and <jats:italic toggle="yes">r</jats:italic> = −0.42, <jats:italic toggle="yes">P</jats:italic> <.001, respectively), whereas those in LDH and CRP were not. Moreover, longitudinal changes in serum KL-6 were significantly associated with recurrence of ARS-IP and could be used to detect ARS-IP recurrence; the area under the curve was 0.79 (<jats:italic toggle="yes">P</jats:italic> = .002).</jats:p> <jats:p>The present study demonstrated that serial measurement of KL-6 is useful for monitoring disease activity and detecting recurrence of ARS-IP.</jats:p> </jats:sec>
Journal
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- Medicine
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Medicine 97 (49), e13542-, 2018-12
Ovid Technologies (Wolters Kluwer Health)
- Tweet
Keywords
- Adult
- Male
- anti-aminoacyl-tRNA synthetase antibody
- Observational Study
- Amino Acyl-tRNA Synthetases
- Recurrence
- Humans
- Longitudinal Studies
- monitoring marker
- Autoantibodies
- Retrospective Studies
- Aged, 80 and over
- interstitial lung disease
- 6700
- Mucin-1
- KL-6
- Middle Aged
- Female
- Lung Diseases, Interstitial
- Biomarkers
- Research Article
Details 詳細情報について
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- CRID
- 1360567184852703360
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- ISSN
- 15365964
- 00257974
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- PubMed
- 30544464
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- Data Source
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- Crossref
- KAKEN
- OpenAIRE