Sex-Specific Posttranslational Regulation of the Gamete Fusogen GCS1 in the Isogamous Volvocine Alga Gonium pectorale

  • Hiroko Kawai-Toyooka
    Department of Biological Sciences, Graduate School of Science, University of Tokyo, Tokyo, Japan
  • Toshiyuki Mori
    Waseda Institute for Advanced Study, Waseda University, Tokyo, Japan
  • Takashi Hamaji
    Department of Botany, Graduate School of Science, Kyoto University, Kyoto, Japan
  • Masahiro Suzuki
    Department of Biological Sciences, Graduate School of Science, University of Tokyo, Tokyo, Japan
  • Bradley J. S. C. Olson
    Ecological Genomics Institute, The Division of Biology, Kansas State University, Manhattan, Kansas, USA
  • Tomohiro Uemura
    Department of Biological Sciences, Graduate School of Science, University of Tokyo, Tokyo, Japan
  • Takashi Ueda
    Department of Biological Sciences, Graduate School of Science, University of Tokyo, Tokyo, Japan
  • Akihiko Nakano
    Department of Biological Sciences, Graduate School of Science, University of Tokyo, Tokyo, Japan
  • Atsushi Toyoda
    Comparative Genomics Laboratory, National Institute of Genetics, Shizuoka, Japan
  • Asao Fujiyama
    Comparative Genomics Laboratory, National Institute of Genetics, Shizuoka, Japan
  • Hisayoshi Nozaki
    Department of Biological Sciences, Graduate School of Science, University of Tokyo, Tokyo, Japan

説明

<jats:title>ABSTRACT</jats:title> <jats:p> Male and female, generally defined based on differences in gamete size and motility, likely have multiple independent origins, appearing to have evolved from isogamous organisms in various eukaryotic lineages. Recent studies of the gamete fusogen GCS1/HAP2 indicate that this protein is deeply conserved across eukaryotes, and its exclusive and/or functional expression generally resides in males or in male homologues. However, little is known regarding the conserved or primitive molecular traits of males and females within eukaryotes. Here, using morphologically indistinguishable isogametes of the colonial volvocine <jats:named-content content-type="genus-species">Gonium pectorale</jats:named-content> , we demonstrated that GCS1 is differently regulated between the sexes. <jats:named-content content-type="genus-species">G. pectorale</jats:named-content> GCS1 molecules in one sex (homologous to male) are transported from the gamete cytoplasm to the protruded fusion site, whereas those of the other sex (females) are quickly degraded within the cytoplasm upon gamete activation. This molecular trait difference might be conserved across various eukaryotic lineages and may represent male and female prototypes originating from a common eukaryotic ancestor. </jats:p>

収録刊行物

  • Eukaryotic Cell

    Eukaryotic Cell 13 (5), 648-656, 2014-05

    American Society for Microbiology

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