The Role of Phospholipase in Sperm Physiology and its Therapeutic Potential in Male Infertility
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- Fuminori Kimura
- Department of Obstetrics and Gynecology, Shiga University of Medical Science, Shiga 520-2192, Japan
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- Kazumi Kishida
- Department of Obstetrics and Gynecology, Shiga University of Medical Science, Shiga 520-2192, Japan
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- Chisako Horikawa
- Department of Obstetrics and Gynecology, Shiga University of Medical Science, Shiga 520-2192, Japan
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- Mika Izuno
- Department of Obstetrics and Gynecology, Shiga University of Medical Science, Shiga 520-2192, Japan
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- Akiko Nakamura
- Department of Obstetrics and Gynecology, Shiga University of Medical Science, Shiga 520-2192, Japan
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- Jun Kitazawa
- Department of Obstetrics and Gynecology, Shiga University of Medical Science, Shiga 520-2192, Japan
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- Aina Morimune
- Department of Obstetrics and Gynecology, Shiga University of Medical Science, Shiga 520-2192, Japan
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- Shoko Tsuji
- Department of Obstetrics and Gynecology, Shiga University of Medical Science, Shiga 520-2192, Japan
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- Akie Takebayashi
- Department of Obstetrics and Gynecology, Shiga University of Medical Science, Shiga 520-2192, Japan
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- Akiko Takashima
- Department of Obstetrics and Gynecology, Shiga University of Medical Science, Shiga 520-2192, Japan
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- Shoji Kaku
- Department of Obstetrics and Gynecology, Shiga University of Medical Science, Shiga 520-2192, Japan
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- Takashi Murakami
- Department of Obstetrics and Gynecology, Shiga University of Medical Science, Shiga 520-2192, Japan
説明
In mammals, the role of sperm in the process of fertilization is complex, and several well-defined steps must occur for the sperm to fertilize with the oocyte. Phospholipases (PLs), which regulate the lipid composition of the sperm by hydrolyzation of the phospholipids, are involved in the regulation of the flagellar beat, capacitation, and the acrosomal reaction, as well as in the triggering of the calcium oscillations in the oocyte that lead to oocyte activation. The emerging important role of phospholipases is also revealed by the fact that alterations of sperm lipids can lead to infertility. Phospholipases, especially PLCζ, could represent therapeutic targets to overcome male infertility.
収録刊行物
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- Journal of Mammalian Ova Research
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Journal of Mammalian Ova Research 35 (2), 43-52, 2018-10
Japanese Society of Mammalian Ova Research
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詳細情報 詳細情報について
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- CRID
- 1360567187113062144
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- ISSN
- 13475878
- 13417738
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- 資料種別
- journal article
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- データソース種別
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- Crossref
- KAKEN
- OpenAIRE
