Development of a Simple Genotyping Method for the <i>Hla-A*31:01</i> -Tagging Snp in Japanese
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- Keiko Maekawa
- Division of Medicinal Safety Science, National Institute of Health Sciences, 1–18–1 Kamiyoga, Setagaya-ku, Tokyo 158–8501, Japan
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- Ryosuke Nakamura
- Division of Medicinal Safety Science, National Institute of Health Sciences, 1–18–1 Kamiyoga, Setagaya-ku, Tokyo 158–8501, Japan
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- Nahoko Kaniwa
- Division of Medicinal Safety Science, National Institute of Health Sciences, 1–18–1 Kamiyoga, Setagaya-ku, Tokyo 158–8501, Japan
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- Seiho Mizusawa
- EBM Research Center, Kyoto University Graduate School of Medicine, Yoshida-Konoecho, Sakyo-ku, Kyoto 606–8501, Japan
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- Aya Kitamoto
- EBM Research Center, Kyoto University Graduate School of Medicine, Yoshida-Konoecho, Sakyo-ku, Kyoto 606–8501, Japan
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- Takuya Kitamoto
- EBM Research Center, Kyoto University Graduate School of Medicine, Yoshida-Konoecho, Sakyo-ku, Kyoto 606–8501, Japan
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- Maho Ukaji
- Division of Medicinal Safety Science, National Institute of Health Sciences, 1–18–1 Kamiyoga, Setagaya-ku, Tokyo 158–8501, Japan
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- Yumiko Matsuzawa
- Division of Medicinal Safety Science, National Institute of Health Sciences, 1–18–1 Kamiyoga, Setagaya-ku, Tokyo 158–8501, Japan
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- Emiko Sugiyama
- Division of Medicinal Safety Science, National Institute of Health Sciences, 1–18–1 Kamiyoga, Setagaya-ku, Tokyo 158–8501, Japan
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- Yoshimi Uchida
- Division of Medicinal Safety Science, National Institute of Health Sciences, 1–18–1 Kamiyoga, Setagaya-ku, Tokyo 158–8501, Japan
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- Kouichi Kurose
- Division of Medicinal Safety Science, National Institute of Health Sciences, 1–18–1 Kamiyoga, Setagaya-ku, Tokyo 158–8501, Japan
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- Mayumi Ueta
- Department of Ophthalmology, Kyoto Prefectural University of Medicine, 465 Kajii-cho, Kawaramachi-Hirokoji, Kamigyo-ku, Kyoto 602–0841, Japan
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- Chie Sotozono
- Department of Ophthalmology, Kyoto Prefectural University of Medicine, 465 Kajii-cho, Kawaramachi-Hirokoji, Kamigyo-ku, Kyoto 602–0841, Japan
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- Hiroko Ikeda
- Shizuoka Institute of Epilepsy & Neurological Disorders, National Epilepsy Center, 886 Urushiyama, Aoi-ku, Shizuoka-shi, Shizuoka 420–8688, Japan
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- Akiko Yagami
- Department of Dermatology, Fujita Health University School of Medicine, 1–98 Dengakugakubo, Kutsukake-cho, Toyoake, Aichi 470–1192, Japan
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- Setsuko Matsukura
- Department of Environmental Immuno-dermatology, Yokohama City University Graduate School of Medicine, 3–9 Fukuura, Kanazawa-ku, Yokohama 236–0027, Japan
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- Shigeru Kinoshita
- Department of Frontier Medical Science & Technology for Ophthalmology, Kyoto Prefectural University of Medicine, 465 Kajii-cho, Kawaramachi-Hirokoji, Kamigyo-ku, Kyoto 602–0841, Japan
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- Masaaki Muramatsu
- Molecular Epidemiology, Medical Research Institute, Tokyo Medical & Dental University, 1–5–45 Yushima, Bunkyo-ku, Tokyo 113–0034, Japan
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- Zenro Ikezawa
- Department of Environmental Immuno-dermatology, Yokohama City University Graduate School of Medicine, 3–9 Fukuura, Kanazawa-ku, Yokohama 236–0027, Japan
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- Akihiro Sekine
- EBM Research Center, Kyoto University Graduate School of Medicine, Yoshida-Konoecho, Sakyo-ku, Kyoto 606–8501, Japan
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- Hirokazu Furuya
- Department of Neurology, Kochi Medical School, Kochi University, Oko-cho Kohasu, Nankoku, Kochi 783–8505, Japan
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- Yukitoshi Takahashi
- Shizuoka Institute of Epilepsy & Neurological Disorders, National Epilepsy Center, 886 Urushiyama, Aoi-ku, Shizuoka-shi, Shizuoka 420–8688, Japan
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- Kayoko Matsunaga
- Department of Dermatology, Fujita Health University School of Medicine, 1–98 Dengakugakubo, Kutsukake-cho, Toyoake, Aichi 470–1192, Japan
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- Michiko Aihara
- Department of Environmental Immuno-dermatology, Yokohama City University Graduate School of Medicine, 3–9 Fukuura, Kanazawa-ku, Yokohama 236–0027, Japan
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- Yoshiro Saito
- Division of Medicinal Safety Science, National Institute of Health Sciences, 1–18–1 Kamiyoga, Setagaya-ku, Tokyo 158–8501, Japan
この論文をさがす
説明
To construct a simple, low-cost typing method for the surrogate marker of HLA-A*31:01, a risk factor for carbamazepine (CBZ) related Stevens-Johnson syndrome/toxic epidermal necrolysis (SJS/TEN).DNAs from Japanese SJS/TEN patients were used for genotyping and developing the assay.HLA-A*31:01 was confirmed to be significantly associated with definite/probable cases of CBZ-related SJS/TEN (p = 0.0040). Three single nucleotide polymorphisms, rs1150738, rs3869066 and rs259945, were in absolute linkage disequilibrium with HLA-A*31:01 in 210 Japanese SJS/TEN patients. Robust genotyping of rs3869066 in ZNRD1-AS1 was developed using polymerase chain reaction-restriction fragment length polymorphism assays.Single nucleotide polymorphism genotyping is less time consuming and cheaper than conventional HLA typing, and would be useful for identifying Japanese patients at risk of CBZ-related SJS/TEN.
収録刊行物
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- Pharmacogenomics
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Pharmacogenomics 16 (15), 1689-1699, 2015-10
Informa UK Limited
