Soy Peptide Ingestion Increases Neuroactive Amino Acids in the Adult Brain of Wild-Type and Genetically Engineered Serine-Deficient Mice
説明
The aim of this study was to assess the neurochemical effects produced by short-term dietary soy peptide ingestion in C57BL/6 wild-type mice and in serine-deficient mice that were created as a genetic serine-deficiency disease model. D, L-Amino acid analysis demonstrated that overnight oral ingestion of a 35% (w/v) soy peptide solution significantly increased the hippocampal tissue content of certain neuroactive amino acids in both genotype groups of mice. These amino acids included the neurotransmitter l-glutamate, its precursor L-glutamine, the neuromodulator d-aspartate, and branched-chain amino acids l-valine, l-leucine, and l-isoleucine. Soy peptide ingestion caused similar increases in contents of L-glutamine and branched chain amino acids in the cerebral cortex. Oral ingestion of a 150 mM L-serine solution did not alter contents of these amino acids in the hippocampus and the cerebral cortex in both genotype groups. The present findings indicate that the short-term oral intake of soy peptide positively modulates the levels of certain neuroactive amino acids in the adult brain.
収録刊行物
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- Journal of Nutrition & Food Sciences
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Journal of Nutrition & Food Sciences 01 (04), 2011
OMICS Publishing Group
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詳細情報 詳細情報について
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- CRID
- 1360567189917775616
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- ISSN
- 21559600
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- 資料種別
- journal article
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- データソース種別
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- Crossref
- KAKEN
- OpenAIRE