Soy Peptide Ingestion Increases Neuroactive Amino Acids in the Adult Brain of Wild-Type and Genetically Engineered Serine-Deficient Mice

DOI 被引用文献2件 オープンアクセス

説明

The aim of this study was to assess the neurochemical effects produced by short-term dietary soy peptide ingestion in C57BL/6 wild-type mice and in serine-deficient mice that were created as a genetic serine-deficiency disease model. D, L-Amino acid analysis demonstrated that overnight oral ingestion of a 35% (w/v) soy peptide solution significantly increased the hippocampal tissue content of certain neuroactive amino acids in both genotype groups of mice. These amino acids included the neurotransmitter l-glutamate, its precursor L-glutamine, the neuromodulator d-aspartate, and branched-chain amino acids l-valine, l-leucine, and l-isoleucine. Soy peptide ingestion caused similar increases in contents of L-glutamine and branched chain amino acids in the cerebral cortex. Oral ingestion of a 150 mM L-serine solution did not alter contents of these amino acids in the hippocampus and the cerebral cortex in both genotype groups. The present findings indicate that the short-term oral intake of soy peptide positively modulates the levels of certain neuroactive amino acids in the adult brain.

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詳細情報 詳細情報について

  • CRID
    1360567189917775616
  • DOI
    10.4172/2155-9600.1000109
  • ISSN
    21559600
  • 資料種別
    journal article
  • データソース種別
    • Crossref
    • KAKEN
    • OpenAIRE

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