Adaptive Liquid Interfacially Assembled Protein Nanosheets for Guiding Mesenchymal Stem Cell Fate
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- Xiaofang Jia
- International Center for Materials Nanoarchitectonics (MANA) National Institute for Materials Science (NIMS) 1‐1 Namiki Tsukuba Ibaraki 305‐0044 Japan
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- Kosuke Minami
- International Center for Materials Nanoarchitectonics (MANA) National Institute for Materials Science (NIMS) 1‐1 Namiki Tsukuba Ibaraki 305‐0044 Japan
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- Koichiro Uto
- International Center for Materials Nanoarchitectonics (MANA) National Institute for Materials Science (NIMS) 1‐1 Namiki Tsukuba Ibaraki 305‐0044 Japan
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- Alice Chinghsuan Chang
- International Center for Materials Nanoarchitectonics (MANA) National Institute for Materials Science (NIMS) 1‐1 Namiki Tsukuba Ibaraki 305‐0044 Japan
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- Jonathan P. Hill
- International Center for Materials Nanoarchitectonics (MANA) National Institute for Materials Science (NIMS) 1‐1 Namiki Tsukuba Ibaraki 305‐0044 Japan
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- Jun Nakanishi
- International Center for Materials Nanoarchitectonics (MANA) National Institute for Materials Science (NIMS) 1‐1 Namiki Tsukuba Ibaraki 305‐0044 Japan
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- Katsuhiko Ariga
- International Center for Materials Nanoarchitectonics (MANA) National Institute for Materials Science (NIMS) 1‐1 Namiki Tsukuba Ibaraki 305‐0044 Japan
書誌事項
- 公開日
- 2019-12-09
- 資源種別
- journal article
- 権利情報
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- http://onlinelibrary.wiley.com/termsAndConditions#am
- http://onlinelibrary.wiley.com/termsAndConditions#vor
- DOI
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- 10.1002/adma.201905942
- 公開者
- Wiley
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説明
<jats:title>Abstract</jats:title><jats:p>There is a growing interest in the development of dynamic adaptive biomaterials for regulation of cellular functions. However, existing materials are limited to two‐state switching of the presentation and removal of cell‐adhesive bioactive motifs that cannot emulate the native extracellular matrix (ECM) in vivo with continuously adjustable characteristics. Here, tunable adaptive materials composed of a protein monolayer assembled at a liquid–liquid interface are demonstrated, which adapt dynamically to cell traction forces. An ultrastructure transition from protein monolayer to hierarchical fiber occurs through interfacial jamming. Elongated fibronectin fibers promote formation of elongated focal adhesion structures, increase focal adhesion kinase activation, and enhance neuronal differentiation of stem cells. Cell traction force results in spatial rearrangement of ECM proteins, which feeds back to alter stem cell fate. The reported biomimetic adaptive liquid interface enables dynamic control of stem cell behavior and has potential translational applications.</jats:p>
収録刊行物
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- Advanced Materials
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Advanced Materials 32 (4), 1905942-, 2019-12-09
Wiley
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詳細情報 詳細情報について
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- CRID
- 1360568464403248128
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- ISSN
- 15214095
- 09359648
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- PubMed
- 31814174
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- Web Site
- https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1002%2Fadma.201905942
- https://onlinelibrary.wiley.com/doi/pdf/10.1002/adma.201905942
- https://onlinelibrary.wiley.com/doi/full-xml/10.1002/adma.201905942
- https://advanced.onlinelibrary.wiley.com/doi/am-pdf/10.1002/adma.201905942
- https://advanced.onlinelibrary.wiley.com/doi/pdf/10.1002/adma.201905942
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- 資料種別
- journal article
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- データソース種別
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- KAKEN
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