Membraneless polyester microdroplets as primordial compartments at the origins of life

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  • Tony Z. Jia
    Earth-Life Science Institute, Tokyo Institute of Technology, Meguro-ku, 152-8550 Tokyo, Japan;
  • Kuhan Chandru
    Earth-Life Science Institute, Tokyo Institute of Technology, Meguro-ku, 152-8550 Tokyo, Japan;
  • Yayoi Hongo
    Earth-Life Science Institute, Tokyo Institute of Technology, Meguro-ku, 152-8550 Tokyo, Japan;
  • Rehana Afrin
    Earth-Life Science Institute, Tokyo Institute of Technology, Meguro-ku, 152-8550 Tokyo, Japan;
  • Tomohiro Usui
    Earth-Life Science Institute, Tokyo Institute of Technology, Meguro-ku, 152-8550 Tokyo, Japan;
  • Kunihiro Myojo
    Department of Earth and Planetary Sciences, Tokyo Institute of Technology, Meguro-ku, 152-8551 Tokyo, Japan;
  • H. James Cleaves
    Earth-Life Science Institute, Tokyo Institute of Technology, Meguro-ku, 152-8550 Tokyo, Japan;

説明

<jats:title>Significance</jats:title><jats:p>The prebiotic milieu was likely heterogeneous, consisting of a large number of chemicals and their associated reactions, including those not only of biological compounds, but also nonbiological compounds. Although origins of life research has focused primarily on biological molecules, the nonbiological molecules which were also present may have assisted evolving chemical systems in unforeseen ways. Thus, we synthesized and assembled membraneless polyester microdroplets from drying of pools of simple α-hydroxy acid monomers and showed that they can act as plausible prebiotic compartments. By having the capacity to undergo combinatorial rearrangement, these microdroplets could have developed versatile abilities to host early genetic and metabolic systems critical for the origins of life.</jats:p>

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