Helicobacter pylori Virulence Factors Exploiting Gastric Colonization and its Pathogenicity
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- Shamshul Ansari
- Department of Microbiology, Chitwan Medical College and Teaching Hospital, Bharatpur 44200, Chitwan, Nepal
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- Yoshio Yamaoka
- Department of Environmental and Preventive Medicine, Oita University Faculty of Medicine, Idaigaoka, Hasama-machi, Yufu, Oita 879-5593, Japan
書誌事項
- 公開日
- 2019-11-19
- 資源種別
- journal article
- 権利情報
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- https://creativecommons.org/licenses/by/4.0/
- DOI
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- 10.3390/toxins11110677
- 公開者
- MDPI AG
説明
<jats:p>Helicobacter pylori colonizes the gastric epithelial cells of at least half of the world’s population, and it is the strongest risk factor for developing gastric complications like chronic gastritis, ulcer diseases, and gastric cancer. To successfully colonize and establish a persistent infection, the bacteria must overcome harsh gastric conditions. H. pylori has a well-developed mechanism by which it can survive in a very acidic niche. Despite bacterial factors, gastric environmental factors and host genetic constituents together play a co-operative role for gastric pathogenicity. The virulence factors include bacterial colonization factors BabA, SabA, OipA, and HopQ, and the virulence factors necessary for gastric pathogenicity include the effector proteins like CagA, VacA, HtrA, and the outer membrane vesicles. Bacterial factors are considered more important. Here, we summarize the recent information to better understand several bacterial virulence factors and their role in the pathogenic mechanism.</jats:p>
収録刊行物
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- Toxins
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Toxins 11 (11), 677-, 2019-11-19
MDPI AG
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キーワード
詳細情報 詳細情報について
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- CRID
- 1360568619470945792
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- ISSN
- 20726651
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- 資料種別
- journal article
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- データソース種別
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- Crossref
- KAKEN
- OpenAIRE