Genetic Characterization of Streptococcus pyogenes emm89 Strains Isolated in Japan From 2011 to 2019
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- Yujiro Hirose
- Department of Oral and Molecular Microbiology, Osaka University Graduate School of Dentistry, Suita, Osaka, Japan
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- Masaya Yamaguchi
- Department of Oral and Molecular Microbiology, Osaka University Graduate School of Dentistry, Suita, Osaka, Japan
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- Norihiko Takemoto
- Department of Infectious Diseases, Research Institute, National Center for Global Health and Medicine, Tokyo, Japan
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- Tohru Miyoshi-Akiyama
- Department of Infectious Diseases, Research Institute, National Center for Global Health and Medicine, Tokyo, Japan
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- Tomoko Sumitomo
- Department of Oral and Molecular Microbiology, Osaka University Graduate School of Dentistry, Suita, Osaka, Japan
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- Masanobu Nakata
- Department of Oral Microbiology, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan
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- Tadayoshi Ikebe
- Department of Bacteriology I, National Institute of Infectious Diseases, Tokyo, Japan
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- Tomoki Hanada
- Department of Oral and Molecular Microbiology, Osaka University Graduate School of Dentistry, Suita, Osaka, Japan
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- Takahiro Yamaguchi
- Division of Microbiology, Osaka Institute of Public Health, Osaka City, Osaka, Japan
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- Ryuji Kawahara
- Division of Microbiology, Osaka Institute of Public Health, Osaka City, Osaka, Japan
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- Rumi Okuno
- Department of Microbiology, Tokyo Metropolitan Institute of Public Health, Tokyo, Japan
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- Hitoshi Otsuka
- Department of Public Health Sciences, Yamaguchi Prefectural Institute of Public Health and Environment Yamaguchi City, Yamaguchi, Japan
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- Yuko Matsumoto
- Microbiological Testing and Research Division, Yokohama City Institute of Public Health, Yokohama, Kanagawa, Japan
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- Yuji Terashima
- Department of Microbiology, Fukushima Prefectural Institute of Public Health, Fukushima City, Fukushima, Japan
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- Yu Kazawa
- Department of Microbiology, Fukushima Prefectural Institute of Public Health, Fukushima City, Fukushima, Japan
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- Noriko Nakanishi
- Department of Infectious Diseases, Kobe Institute of Health, Kobe, Hyogo, Japan
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- Kaoru Uchida
- Department of Bacteriology, Toyama Institute of Health, Imizu, Toyama, Japan
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- Yumi Akiyama
- Infectious Disease Research Division, Hyogo Prefectural Institute of Public Health Science, Kakogawa, Hyogo, Japan
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- Kaori Iwabuchi
- Department of Health Science, Iwate Prefectural Research Institute for Environmental Sciences and Public Health, Morioka, Iwate, Japan
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- Chikara Nakagawa
- Division of Microbiology, Kyoto City Institute of Health and Environmental Sciences, Kyoto City, Kyoto, Japan
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- Kazunari Yamamoto
- Niigata City Institute of Public Health and the Environment, Niigata City, Niigata, Japan
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- Victor Nizet
- Department of Pediatrics, University of California at San Diego School of Medicine, La Jolla, CA, USA
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- Shigetada Kawabata
- Department of Oral and Molecular Microbiology, Osaka University Graduate School of Dentistry, Suita, Osaka, Japan
抄録
<jats:sec> <jats:title>Abstract</jats:title> <jats:p>Invasive infection caused by <jats:italic toggle="yes">Streptococcus pyogenes emm</jats:italic>89 strains has been increasing in several countries linked to a recently emergent clade of <jats:italic toggle="yes">emm</jats:italic>89 strains, designated clade 3. In Japan, the features of <jats:italic toggle="yes">emm</jats:italic>89 <jats:italic toggle="yes">S. pyogenes</jats:italic> strains, such as clade classification, remains unknown. In this study, we collected <jats:italic toggle="yes">emm</jats:italic>89 strains isolated from both streptococcal toxic shock syndrome (STSS) (89 STSS isolates) and noninvasive infections (72 non-STSS isolates) in Japan from 2011 to 2019, and conducted whole-genome sequencing and comparative analysis, which resulted in classification of a large majority into clade 3 regardless of disease severity. In addition, invasive disease-associated factors were found among <jats:italic toggle="yes">emm</jats:italic>89 strains, including mutations of control of virulence sensor, and absence of the <jats:italic toggle="yes">hylP1</jats:italic> gene encoding hyaluronidase. These findings provide new insights into genetic features of <jats:italic toggle="yes">emm</jats:italic>89 strains.</jats:p> </jats:sec>
収録刊行物
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- Infectious Microbes and Diseases
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Infectious Microbes and Diseases 2 (4), 160-166, 2020-10-21
Ovid Technologies (Wolters Kluwer Health)