Genetic Characterization of Streptococcus pyogenes emm89 Strains Isolated in Japan From 2011 to 2019

DOI Web Site 29 References Open Access
  • Yujiro Hirose
    Department of Oral and Molecular Microbiology, Osaka University Graduate School of Dentistry, Suita, Osaka, Japan
  • Masaya Yamaguchi
    Department of Oral and Molecular Microbiology, Osaka University Graduate School of Dentistry, Suita, Osaka, Japan
  • Norihiko Takemoto
    Department of Infectious Diseases, Research Institute, National Center for Global Health and Medicine, Tokyo, Japan
  • Tohru Miyoshi-Akiyama
    Department of Infectious Diseases, Research Institute, National Center for Global Health and Medicine, Tokyo, Japan
  • Tomoko Sumitomo
    Department of Oral and Molecular Microbiology, Osaka University Graduate School of Dentistry, Suita, Osaka, Japan
  • Masanobu Nakata
    Department of Oral Microbiology, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan
  • Tadayoshi Ikebe
    Department of Bacteriology I, National Institute of Infectious Diseases, Tokyo, Japan
  • Tomoki Hanada
    Department of Oral and Molecular Microbiology, Osaka University Graduate School of Dentistry, Suita, Osaka, Japan
  • Takahiro Yamaguchi
    Division of Microbiology, Osaka Institute of Public Health, Osaka City, Osaka, Japan
  • Ryuji Kawahara
    Division of Microbiology, Osaka Institute of Public Health, Osaka City, Osaka, Japan
  • Rumi Okuno
    Department of Microbiology, Tokyo Metropolitan Institute of Public Health, Tokyo, Japan
  • Hitoshi Otsuka
    Department of Public Health Sciences, Yamaguchi Prefectural Institute of Public Health and Environment Yamaguchi City, Yamaguchi, Japan
  • Yuko Matsumoto
    Microbiological Testing and Research Division, Yokohama City Institute of Public Health, Yokohama, Kanagawa, Japan
  • Yuji Terashima
    Department of Microbiology, Fukushima Prefectural Institute of Public Health, Fukushima City, Fukushima, Japan
  • Yu Kazawa
    Department of Microbiology, Fukushima Prefectural Institute of Public Health, Fukushima City, Fukushima, Japan
  • Noriko Nakanishi
    Department of Infectious Diseases, Kobe Institute of Health, Kobe, Hyogo, Japan
  • Kaoru Uchida
    Department of Bacteriology, Toyama Institute of Health, Imizu, Toyama, Japan
  • Yumi Akiyama
    Infectious Disease Research Division, Hyogo Prefectural Institute of Public Health Science, Kakogawa, Hyogo, Japan
  • Kaori Iwabuchi
    Department of Health Science, Iwate Prefectural Research Institute for Environmental Sciences and Public Health, Morioka, Iwate, Japan
  • Chikara Nakagawa
    Division of Microbiology, Kyoto City Institute of Health and Environmental Sciences, Kyoto City, Kyoto, Japan
  • Kazunari Yamamoto
    Niigata City Institute of Public Health and the Environment, Niigata City, Niigata, Japan
  • Victor Nizet
    Department of Pediatrics, University of California at San Diego School of Medicine, La Jolla, CA, USA
  • Shigetada Kawabata
    Department of Oral and Molecular Microbiology, Osaka University Graduate School of Dentistry, Suita, Osaka, Japan

Abstract

<jats:sec> <jats:title>Abstract</jats:title> <jats:p>Invasive infection caused by <jats:italic toggle="yes">Streptococcus pyogenes emm</jats:italic>89 strains has been increasing in several countries linked to a recently emergent clade of <jats:italic toggle="yes">emm</jats:italic>89 strains, designated clade 3. In Japan, the features of <jats:italic toggle="yes">emm</jats:italic>89 <jats:italic toggle="yes">S. pyogenes</jats:italic> strains, such as clade classification, remains unknown. In this study, we collected <jats:italic toggle="yes">emm</jats:italic>89 strains isolated from both streptococcal toxic shock syndrome (STSS) (89 STSS isolates) and noninvasive infections (72 non-STSS isolates) in Japan from 2011 to 2019, and conducted whole-genome sequencing and comparative analysis, which resulted in classification of a large majority into clade 3 regardless of disease severity. In addition, invasive disease-associated factors were found among <jats:italic toggle="yes">emm</jats:italic>89 strains, including mutations of control of virulence sensor, and absence of the <jats:italic toggle="yes">hylP1</jats:italic> gene encoding hyaluronidase. These findings provide new insights into genetic features of <jats:italic toggle="yes">emm</jats:italic>89 strains.</jats:p> </jats:sec>

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