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Stromal metalloproteinases: Crucial contributors to the tumor microenvironment
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- Masayuki Shimoda
- Department of Pathology Keio University School of Medicine Tokyo Japan
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- Takashi Ohtsuka
- Division of Thoracic Surgery, Department of Surgery The Jikei University School of Medicine Tokyo Japan
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- Yasunori Okada
- Department of Pathophysiology for Locomotive and Neoplastic Diseases Juntendo University Graduate School of Medicine Tokyo Japan
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- Yae Kanai
- Department of Pathology Keio University School of Medicine Tokyo Japan
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Description
<jats:p>Proteolytic balance is crucial for the maintenance of tissue homeostasis. In cancer, dysregulated proteolysis is involved in unregulated tissue remodeling and inflammation, leading to the promotion of tumor growth, local invasion, and metastasis. Metalloproteinases, which were first identified as collagen cleaving enzymes, have been shown to extensively degrade extracellular matrix proteins or selectively release cell surface‐bound cytokines, growth factors, or their receptors, thereby impacting extracellular matrix integrity, immune cell recruitment and tissue turnover. Although tumor cells produce various metalloproteinases, the major source is thought to be stromal cells infiltrating the tumor. Different types of stromal cells express specific sets of metalloproteinases and their inhibitors, which specifically alter the milieu within the tumor. In this review, recent findings and knowledge regarding metalloproteinases derived from stromal cells during the creation of the tumor microenvironment are described and their contribution to the tumor progression and metastasis discussed.</jats:p>
Journal
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- Pathology International
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Pathology International 71 (1), 1-14, 2020-10-19
Wiley