Transcriptional Regulatory Networks in <i>Saccharomyces cerevisiae</i>

DOI Web Site 被引用文献22件
  • Tong Ihn Lee
    Whitehead Institute for Biomedical Research, Nine Cambridge Center, Cambridge, MA 02142, USA.
  • Nicola J. Rinaldi
    Whitehead Institute for Biomedical Research, Nine Cambridge Center, Cambridge, MA 02142, USA.
  • François Robert
    Whitehead Institute for Biomedical Research, Nine Cambridge Center, Cambridge, MA 02142, USA.
  • Duncan T. Odom
    Whitehead Institute for Biomedical Research, Nine Cambridge Center, Cambridge, MA 02142, USA.
  • Ziv Bar-Joseph
    MIT Laboratory of Computer Science, 200 Technology Square, Cambridge, MA 02139, USA.
  • Georg K. Gerber
    MIT Laboratory of Computer Science, 200 Technology Square, Cambridge, MA 02139, USA.
  • Nancy M. Hannett
    Whitehead Institute for Biomedical Research, Nine Cambridge Center, Cambridge, MA 02142, USA.
  • Christopher T. Harbison
    Whitehead Institute for Biomedical Research, Nine Cambridge Center, Cambridge, MA 02142, USA.
  • Craig M. Thompson
    Whitehead Institute for Biomedical Research, Nine Cambridge Center, Cambridge, MA 02142, USA.
  • Itamar Simon
    Whitehead Institute for Biomedical Research, Nine Cambridge Center, Cambridge, MA 02142, USA.
  • Julia Zeitlinger
    Whitehead Institute for Biomedical Research, Nine Cambridge Center, Cambridge, MA 02142, USA.
  • Ezra G. Jennings
    Whitehead Institute for Biomedical Research, Nine Cambridge Center, Cambridge, MA 02142, USA.
  • Heather L. Murray
    Whitehead Institute for Biomedical Research, Nine Cambridge Center, Cambridge, MA 02142, USA.
  • D. Benjamin Gordon
    Whitehead Institute for Biomedical Research, Nine Cambridge Center, Cambridge, MA 02142, USA.
  • Bing Ren
    Whitehead Institute for Biomedical Research, Nine Cambridge Center, Cambridge, MA 02142, USA.
  • John J. Wyrick
    Whitehead Institute for Biomedical Research, Nine Cambridge Center, Cambridge, MA 02142, USA.
  • Jean-Bosco Tagne
    Whitehead Institute for Biomedical Research, Nine Cambridge Center, Cambridge, MA 02142, USA.
  • Thomas L. Volkert
    Whitehead Institute for Biomedical Research, Nine Cambridge Center, Cambridge, MA 02142, USA.
  • Ernest Fraenkel
    Whitehead Institute for Biomedical Research, Nine Cambridge Center, Cambridge, MA 02142, USA.
  • David K. Gifford
    MIT Laboratory of Computer Science, 200 Technology Square, Cambridge, MA 02139, USA.
  • Richard A. Young
    Whitehead Institute for Biomedical Research, Nine Cambridge Center, Cambridge, MA 02142, USA.

説明

<jats:p> We have determined how most of the transcriptional regulators encoded in the eukaryote <jats:italic>Saccharomyces cerevisiae</jats:italic> associate with genes across the genome in living cells. Just as maps of metabolic networks describe the potential pathways that may be used by a cell to accomplish metabolic processes, this network of regulator-gene interactions describes potential pathways yeast cells can use to regulate global gene expression programs. We use this information to identify network motifs, the simplest units of network architecture, and demonstrate that an automated process can use motifs to assemble a transcriptional regulatory network structure. Our results reveal that eukaryotic cellular functions are highly connected through networks of transcriptional regulators that regulate other transcriptional regulators. </jats:p>

収録刊行物

  • Science

    Science 298 (5594), 799-804, 2002-10-25

    American Association for the Advancement of Science (AAAS)

被引用文献 (22)*注記

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