BAFF- and APRIL-Dependent Maintenance of Antibody Titers after Immunization with T-Dependent Antigen and CD1d-Binding Ligand

DOI PDF 被引用文献1件
  • Hemangi B Shah
    Department of Microbiology and Immunology, University of Oklahoma Health Sciences Center , Oklahoma City, OK 73104
  • Sunil K Joshi
    Department of Microbiology and Immunology, University of Oklahoma Health Sciences Center , Oklahoma City, OK 73104
  • Pragya Rampuria
    Department of Microbiology and Immunology, University of Oklahoma Health Sciences Center , Oklahoma City, OK 73104
  • T Scott Devera
    Department of Microbiology and Immunology, University of Oklahoma Health Sciences Center , Oklahoma City, OK 73104
  • Gillian A Lang
    Department of Microbiology and Immunology, University of Oklahoma Health Sciences Center , Oklahoma City, OK 73104
  • William Stohl
    Division of Rheumatology, Department of Medicine, University of Southern California Keck School of Medicine , Los Angeles, CA 90033
  • Mark L Lang
    Department of Microbiology and Immunology, University of Oklahoma Health Sciences Center , Oklahoma City, OK 73104

書誌事項

公開日
2013-08-01
権利情報
  • https://academic.oup.com/pages/standard-publication-reuse-rights
DOI
  • 10.4049/jimmunol.1300263
公開者
Oxford University Press (OUP)

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説明

<jats:title>Abstract</jats:title> <jats:p>CD1d-restricted invariant NKT (iNKT) cells boost humoral immunity to T-dependent Ags that are coadministered with the CD1d-binding glycolipid Ag α-galactosylceramide (α-GC). Observations that mice lacking iNKT cells have decaying Ab responses following vaccination have led to the hypothesis that iNKT cells express plasma cell (PC) survival factors that sustain specific Ab titers. Bone marrow chimeric mice in which the entire hematopoietic compartment or iNKT cells selectively lacked BAFF, a proliferation-inducing ligand (APRIL), or both BAFF and APRIL were created and immunized with nitrophenol hapten-conjugated keyhole limpet hemocyanin adsorbed to Imject aluminum hydroxide–containing adjuvant or mixed with α-GC. In comparison with BAFF- or APRIL-sufficient bone marrow chimeras, absence of hematopoietic compartment- and iNKT-derived BAFF and APRIL was associated with rapidly decaying Ab titers and reduced PC numbers. The iNKT cell–derived BAFF or APRIL assumed a greater role in PC survival when α-GC was used as the adjuvant for immunization. These results show that iNKT cell–derived BAFF and APRIL each contribute to survival of PCs induced by immunization. This study sheds new light on the mechanisms through which iNKT cells impact humoral immunity and may inform design of vaccines that incorporate glycolipid adjuvants.</jats:p>

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