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- Leo E. Otterbein
- From the Department of Surgery, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA (L.E.O.); INSERM, U955, Equipe 12, Créteil, France (R.F., R.M.); and University Paris Est, Faculty of Medicine, Créteil, France (R.F., R.M.).
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- Roberta Foresti
- From the Department of Surgery, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA (L.E.O.); INSERM, U955, Equipe 12, Créteil, France (R.F., R.M.); and University Paris Est, Faculty of Medicine, Créteil, France (R.F., R.M.).
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- Roberto Motterlini
- From the Department of Surgery, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA (L.E.O.); INSERM, U955, Equipe 12, Créteil, France (R.F., R.M.); and University Paris Est, Faculty of Medicine, Créteil, France (R.F., R.M.).
書誌事項
- タイトル別名
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- The Balancing Act Between Danger Signaling and Pro-Survival
- 公開日
- 2016-06-10
- DOI
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- 10.1161/circresaha.116.306588
- 公開者
- Ovid Technologies (Wolters Kluwer Health)
この論文をさがす
説明
<jats:p>Understanding the processes governing the ability of the heart to repair and regenerate after injury is crucial for developing translational medical solutions. New avenues of exploration include cardiac cell therapy and cellular reprogramming targeting cell death and regeneration. An attractive possibility is the exploitation of cytoprotective genes that exist solely for self-preservation processes and serve to promote and support cell survival. Although the antioxidant and heat-shock proteins are included in this category, one enzyme that has received a great deal of attention as a master protective sentinel is heme oxygenase-1 (HO-1), the rate-limiting step in the catabolism of heme into the bioactive signaling molecules carbon monoxide, biliverdin, and iron. The remarkable cardioprotective effects ascribed to heme oxygenase-1 are best evidenced by its ability to regulate inflammatory processes, cellular signaling, and mitochondrial function ultimately mitigating myocardial tissue injury and the progression of vascular-proliferative disease. We discuss here new insights into the role of heme oxygenase-1 and heme on cardiovascular health, and importantly, how they might be leveraged to promote heart repair after injury.</jats:p>
収録刊行物
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- Circulation Research
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Circulation Research 118 (12), 1940-1959, 2016-06-10
Ovid Technologies (Wolters Kluwer Health)