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- Changbin Shi
- From the Department of Neurological Surgery (C.S., I.A.A., Z.A.H., R.S., C.C.G., M.B., H.H.B., B.R.B.), Center for Genetic Medicine (N.J., M.B.), and Robert H. Lurie Comprehensive Cancer Center (S.L., P.D., M.B.), Feinberg School of Medicine, Northwestern University, Chicago, Ill, and Division of Neurosurgery (C.S., I.A.A., R.S.), Northshore University HealthSystem, Evanston, Ill.
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- Issam A. Awad
- From the Department of Neurological Surgery (C.S., I.A.A., Z.A.H., R.S., C.C.G., M.B., H.H.B., B.R.B.), Center for Genetic Medicine (N.J., M.B.), and Robert H. Lurie Comprehensive Cancer Center (S.L., P.D., M.B.), Feinberg School of Medicine, Northwestern University, Chicago, Ill, and Division of Neurosurgery (C.S., I.A.A., R.S.), Northshore University HealthSystem, Evanston, Ill.
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- Nadereh Jafari
- From the Department of Neurological Surgery (C.S., I.A.A., Z.A.H., R.S., C.C.G., M.B., H.H.B., B.R.B.), Center for Genetic Medicine (N.J., M.B.), and Robert H. Lurie Comprehensive Cancer Center (S.L., P.D., M.B.), Feinberg School of Medicine, Northwestern University, Chicago, Ill, and Division of Neurosurgery (C.S., I.A.A., R.S.), Northshore University HealthSystem, Evanston, Ill.
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- Simon Lin
- From the Department of Neurological Surgery (C.S., I.A.A., Z.A.H., R.S., C.C.G., M.B., H.H.B., B.R.B.), Center for Genetic Medicine (N.J., M.B.), and Robert H. Lurie Comprehensive Cancer Center (S.L., P.D., M.B.), Feinberg School of Medicine, Northwestern University, Chicago, Ill, and Division of Neurosurgery (C.S., I.A.A., R.S.), Northshore University HealthSystem, Evanston, Ill.
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- Pan Du
- From the Department of Neurological Surgery (C.S., I.A.A., Z.A.H., R.S., C.C.G., M.B., H.H.B., B.R.B.), Center for Genetic Medicine (N.J., M.B.), and Robert H. Lurie Comprehensive Cancer Center (S.L., P.D., M.B.), Feinberg School of Medicine, Northwestern University, Chicago, Ill, and Division of Neurosurgery (C.S., I.A.A., R.S.), Northshore University HealthSystem, Evanston, Ill.
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- Ziad A. Hage
- From the Department of Neurological Surgery (C.S., I.A.A., Z.A.H., R.S., C.C.G., M.B., H.H.B., B.R.B.), Center for Genetic Medicine (N.J., M.B.), and Robert H. Lurie Comprehensive Cancer Center (S.L., P.D., M.B.), Feinberg School of Medicine, Northwestern University, Chicago, Ill, and Division of Neurosurgery (C.S., I.A.A., R.S.), Northshore University HealthSystem, Evanston, Ill.
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- Robert Shenkar
- From the Department of Neurological Surgery (C.S., I.A.A., Z.A.H., R.S., C.C.G., M.B., H.H.B., B.R.B.), Center for Genetic Medicine (N.J., M.B.), and Robert H. Lurie Comprehensive Cancer Center (S.L., P.D., M.B.), Feinberg School of Medicine, Northwestern University, Chicago, Ill, and Division of Neurosurgery (C.S., I.A.A., R.S.), Northshore University HealthSystem, Evanston, Ill.
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- Christopher C. Getch
- From the Department of Neurological Surgery (C.S., I.A.A., Z.A.H., R.S., C.C.G., M.B., H.H.B., B.R.B.), Center for Genetic Medicine (N.J., M.B.), and Robert H. Lurie Comprehensive Cancer Center (S.L., P.D., M.B.), Feinberg School of Medicine, Northwestern University, Chicago, Ill, and Division of Neurosurgery (C.S., I.A.A., R.S.), Northshore University HealthSystem, Evanston, Ill.
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- Markus Bredel
- From the Department of Neurological Surgery (C.S., I.A.A., Z.A.H., R.S., C.C.G., M.B., H.H.B., B.R.B.), Center for Genetic Medicine (N.J., M.B.), and Robert H. Lurie Comprehensive Cancer Center (S.L., P.D., M.B.), Feinberg School of Medicine, Northwestern University, Chicago, Ill, and Division of Neurosurgery (C.S., I.A.A., R.S.), Northshore University HealthSystem, Evanston, Ill.
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- H. Hunt Batjer
- From the Department of Neurological Surgery (C.S., I.A.A., Z.A.H., R.S., C.C.G., M.B., H.H.B., B.R.B.), Center for Genetic Medicine (N.J., M.B.), and Robert H. Lurie Comprehensive Cancer Center (S.L., P.D., M.B.), Feinberg School of Medicine, Northwestern University, Chicago, Ill, and Division of Neurosurgery (C.S., I.A.A., R.S.), Northshore University HealthSystem, Evanston, Ill.
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- Bernard R. Bendok
- From the Department of Neurological Surgery (C.S., I.A.A., Z.A.H., R.S., C.C.G., M.B., H.H.B., B.R.B.), Center for Genetic Medicine (N.J., M.B.), and Robert H. Lurie Comprehensive Cancer Center (S.L., P.D., M.B.), Feinberg School of Medicine, Northwestern University, Chicago, Ill, and Division of Neurosurgery (C.S., I.A.A., R.S.), Northshore University HealthSystem, Evanston, Ill.
書誌事項
- 公開日
- 2009-04
- DOI
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- 10.1161/strokeaha.108.532036
- 公開者
- Ovid Technologies (Wolters Kluwer Health)
この論文をさがす
説明
<jats:p> <jats:bold> <jats:italic>Background and Purpose—</jats:italic> </jats:bold> The pathogenesis of intracranial aneurysms (IAs) remains elusive. Most studies have focused on individual genes, or a few interrelated genes or products, at a time in human IA. However, a broad view of pathologic mechanisms has not been investigated by identifying pathogenic genes and their interaction in networks. Our study aimed to analyze global gene expression patterns in the IA wall. </jats:p> <jats:p> <jats:bold> <jats:italic>Methods—</jats:italic> </jats:bold> To our knowledge, our group was the first to perform Illumina microarray analysis on human IA via comparison of aneurysm wall and superficial temporal artery tissues from 6 consecutive patients. We adopted stringent statistical criteria to the individual genes; genes with a false discovery rate <0.01 and >2-fold change were selected as differentially expressed. To identify the overrepresented biologic pathways with the differentially expressed genes, we performed hypergeometric testing of the genes selected by relaxed criteria of <jats:italic>P</jats:italic> <0.01 and fold change >1.5. </jats:p> <jats:p> <jats:bold> <jats:italic>Results—</jats:italic> </jats:bold> There are 326 distinct differentially expressed genes between IA and superficial temporal artery tissues (>2-fold change) with a false discovery rate <0.01. Analysis of the Kyoto Encyclopedia of Genes and Genomes pathways revealed the most impacted functional pathways: focal adhesion, extracellular matrix receptor interaction, and cell communication. Analysis of the Gene Ontology also supported the involvement of another 2 potentially important pathways: inflammatory response and apoptosis. </jats:p> <jats:p> <jats:bold> <jats:italic>Conclusions—</jats:italic> </jats:bold> The differentially expressed genes in the aneurysm wall may shed light on aneurysm pathobiology and provide novel targets for therapeutic intervention. These data will help generate hypotheses for future studies. </jats:p>
収録刊行物
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- Stroke
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Stroke 40 (4), 1252-1261, 2009-04
Ovid Technologies (Wolters Kluwer Health)