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- Federico Valdez
- Department of Biological Sciences, The University of Texas at El Paso, El Paso, Texas, USA
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- Julienne Salvador
- Department of Biological Sciences, The University of Texas at El Paso, El Paso, Texas, USA
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- Pedro M. Palermo
- Department of Biological Sciences, The University of Texas at El Paso, El Paso, Texas, USA
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- Jonathon E. Mohl
- Department of Bioinformatics, The University of Texas at El Paso, El Paso, Texas, USA
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- Kathryn A. Hanley
- Department of Biology, New Mexico State University, Las Cruces, New Mexico, USA
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- Douglas Watts
- Department of Biological Sciences, The University of Texas at El Paso, El Paso, Texas, USA
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- Manuel Llano
- Department of Biological Sciences, The University of Texas at El Paso, El Paso, Texas, USA
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- Mark T. Heise
- editor
説明
<jats:p>We provide evidence that the cellular protein Schlafen 11 (Slfn11) impairs replication of flaviviruses, including West Nile virus (WNV), dengue virus (DENV), and Zika virus (ZIKV). However, replication of single-stranded negative RNA viruses was not affected. Specifically, Slfn11 decreases the infectivity of WNV potentially by preventing virus-induced modifications of the host tRNA repertoire that could lead to enhanced viral protein folding. Furthermore, we demonstrate that Slfn11 is not the limiting factor of this novel broad antiviral pathway.</jats:p>
収録刊行物
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- Journal of Virology
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Journal of Virology 93 (15), e00104-19-, 2019-08
American Society for Microbiology