Apoptosis and antigen affinity limit effector cell differentiation of a single naïve B cell
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- Justin J. Taylor
- Department of Microbiology, Center for Immunology, University of Minnesota Medical School, Minneapolis, MN 55455, USA.
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- Kathryn A. Pape
- Department of Microbiology, Center for Immunology, University of Minnesota Medical School, Minneapolis, MN 55455, USA.
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- Holly R. Steach
- Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98019, USA.
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- Marc K. Jenkins
- Department of Microbiology, Center for Immunology, University of Minnesota Medical School, Minneapolis, MN 55455, USA.
説明
<jats:title>For a single B cell, many roads to take</jats:title> <jats:p> To successfully fight a pathogen, immunological B cells must wage a multipronged attack: They can differentiate into antibody-secreting plasma cells or become T cell–helping germinal center cells, or even long-lived memory cells. But can a single B cell acquire all of these different fates? To find out, Taylor <jats:italic>et al.</jats:italic> tracked the responses of single B cells in mice. Although some B cells acquired only one fate, others differentiated into all three. The authors linked the ability of B cells to differentiate into multiple subsets to their ability to proliferate and resist cell death, and the affinity of their antigen receptor. </jats:p> <jats:p> <jats:italic>Science</jats:italic> , this issue p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6223" page="784" related-article-type="in-this-issue" vol="347" xlink:href="10.1126/science.aaa1342">784</jats:related-article> </jats:p>
収録刊行物
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- Science
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Science 347 (6223), 784-787, 2015-02-13
American Association for the Advancement of Science (AAAS)