Activation of dopamine D<sub>1</sub>‐like receptors excites LTS interneurons of the striatum
説明
<jats:title>Abstract</jats:title><jats:p>Dopamine (DA) has a crucial role in the modulation of striatal neuron activity. Along with projection cells, striatal interneurons receive dense dopaminergic innervation from midbrain neurons, thus, also suggesting that these intrinsic cells represent a synaptic target for DA action in the striatum. In the present study, we investigated the effects of DA on low‐threshold spike (LTS) interneurons of the rat striatum, by means of <jats:italic>in vitro</jats:italic> whole‐cell patch‐clamp electrophysiological recordings. Dopamine depolarized LTS cells, a pharmacological effect prevented by D<jats:sub>1</jats:sub>‐ but not D<jats:sub>2</jats:sub>‐like DA receptor antagonists. The membrane depolarization produced by DA was sufficient to trigger action potential discharge in the recorded cells and was insensitive to tetrodotoxin and glutamate receptor antagonists. In addition, this pharmacological effect was mimicked by D<jats:sub>1</jats:sub>‐ but not D<jats:sub>2</jats:sub>‐like DA receptor agonists, implying the selective involvement of D<jats:sub>1</jats:sub>‐like receptors in this action.</jats:p>
収録刊行物
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- European Journal of Neuroscience
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European Journal of Neuroscience 15 (12), 2049-2052, 2002-06
Wiley
