Myostatin: Expanding horizons

Mridula Sharma, Craig McFarlane, Ravi Kambadur, Himani Kukreti, Sabeera Bonala, Shruti Srinivasan

doi:10.1002/iub.1392

Myostatin: Expanding horizons

DOI Web Site Web Site 被引用文献3件

Mridula Sharma

Department of Biochemistry, Yong Loo Lin School of Medicine National University of Singapore (NUS) Singapore
Craig McFarlane

Department of Cell & Molecular Biology, Brenner Centre for Molecular Medicine Singapore Institute of Clinical Sciences (SICS) Singapore
Ravi Kambadur

Department of Cell & Molecular Biology, Brenner Centre for Molecular Medicine Singapore Institute of Clinical Sciences (SICS) Singapore
Himani Kukreti

Department of Biochemistry, Yong Loo Lin School of Medicine National University of Singapore (NUS) Singapore
Sabeera Bonala

Department of Cell & Molecular Biology, Brenner Centre for Molecular Medicine Singapore Institute of Clinical Sciences (SICS) Singapore
Shruti Srinivasan

Department of Biochemistry, Yong Loo Lin School of Medicine National University of Singapore (NUS) Singapore

書誌事項

公開日: 2015-08

権利情報

http://onlinelibrary.wiley.com/termsAndConditions#vor

DOI

10.1002/iub.1392

公開者: Wiley

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説明

<jats:title>Abstract</jats:title><jats:p>Myostatin is a secreted growth and differentiation factor that belongs to the TGF‐β superfamily. Myostatin is predominantly synthesized and expressed in skeletal muscle and thus exerts a huge impact on muscle growth and function. In keeping with its negative role in myogenesis, myostatin expression is tightly regulated at several levels including epigenetic, transcriptional, post‐transcriptional, and post‐translational. New revelations regarding myostatin regulation also offer mechanisms that could be exploited for developing myostatin antagonists. Increasingly, it is becoming clearer that besides its conventional role in muscle, myostatin plays a critical role in metabolism. Hence, molecular mechanisms by which myostatin regulates several key metabolic processes need to be further explored. © 2015 IUBMB Life, 67(8):589–600, 2015</jats:p>