Evaluation of <i>Helicobacter pylori</i> Immunoglobulin G (IgG), IgA, and IgM Serologic Testing Compared to Stool Antigen Testing

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  • Rosemary C. She
    Department of Pathology, University of Utah School of Medicine, Salt Lake City, Utah
  • Andrew R. Wilson
    Associated Regional University Pathologists Laboratories, Salt Lake City, Utah
  • Christine M. Litwin
    Department of Pathology, University of Utah School of Medicine, Salt Lake City, Utah

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<jats:title>ABSTRACT</jats:title> <jats:p> The utility of <jats:italic>Helicobacter pylori</jats:italic> serology was evaluated in 4,722 specimens and compared to stool antigen detection. Immunoglobulin M (IgM) sensitivity (6.8%) was unacceptably low. Key performance differences were observed in IgG specificity, IgA sensitivity, and specificity between adults and children that may warrant differentiating optimal serologic cutoff values by age. </jats:p>

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