Human polyclonal immunoglobulin G from transchromosomic bovines inhibits MERS-CoV in vivo
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- Thomas Luke
- Viral and Rickettsial Diseases Department, Navy Medical Research Center, The Henry Jackson Foundation for the Advancement of Military Medicine, Silver Spring, MD 20910, USA.
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- Hua Wu
- SAB Biotherapeutics Inc., Sioux Falls, SD 57104, USA.
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- Jincun Zhao
- Department of Microbiology, University of Iowa, Iowa City, IA 52242, USA.
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- Rudragouda Channappanavar
- Department of Microbiology, University of Iowa, Iowa City, IA 52242, USA.
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- Christopher M. Coleman
- Department of Microbiology and Immunology, University of Maryland, School of Medicine, Baltimore, MD 21201, USA.
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- Jin-An Jiao
- SAB Biotherapeutics Inc., Sioux Falls, SD 57104, USA.
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- Hiroaki Matsushita
- SAB Biotherapeutics Inc., Sioux Falls, SD 57104, USA.
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- Ye Liu
- Novavax Inc., Gaithersburg, MD 20878, USA.
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- Elena N. Postnikova
- Integrated Research Facility at Fort Detrick, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Frederick, MD 21702, USA.
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- Britini L. Ork
- Integrated Research Facility at Fort Detrick, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Frederick, MD 21702, USA.
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- Gregory Glenn
- Novavax Inc., Gaithersburg, MD 20878, USA.
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- David Flyer
- Novavax Inc., Gaithersburg, MD 20878, USA.
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- Gabriel Defang
- Department of Virology, Naval Medical Research Unit-3, Cairo FPO AP 09835, Egypt.
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- Kanakatte Raviprakash
- Department of Virology, Naval Medical Research Unit-3, Cairo FPO AP 09835, Egypt.
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- Tadeusz Kochel
- Viral and Rickettsial Diseases Department, Navy Medical Research Center, Silver Spring, MD 20910, USA.
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- Jonathan Wang
- Thermo Fisher Scientific, South San Francisco, CA 94080, USA.
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- Wensheng Nie
- Thermo Fisher Scientific, South San Francisco, CA 94080, USA.
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- Gale Smith
- Novavax Inc., Gaithersburg, MD 20878, USA.
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- Lisa E. Hensley
- Integrated Research Facility at Fort Detrick, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Frederick, MD 21702, USA.
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- Gene G. Olinger
- Integrated Research Facility at Fort Detrick, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Frederick, MD 21702, USA.
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- Jens H. Kuhn
- Integrated Research Facility at Fort Detrick, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Frederick, MD 21702, USA.
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- Michael R. Holbrook
- Integrated Research Facility at Fort Detrick, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Frederick, MD 21702, USA.
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- Reed F. Johnson
- Emerging Viral Pathogens Section, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Frederick, MD 21702, USA.
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- Stanley Perlman
- Department of Microbiology, University of Iowa, Iowa City, IA 52242, USA.
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- Eddie Sullivan
- SAB Biotherapeutics Inc., Sioux Falls, SD 57104, USA.
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- Matthew B. Frieman
- Department of Microbiology and Immunology, University of Maryland, School of Medicine, Baltimore, MD 21201, USA.
抄録
<jats:p>Anti–MERS-CoV human IgG produced from transchromosomic bovines neutralizes MERS-CoV in vitro and in vivo.</jats:p>
収録刊行物
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- Science Translational Medicine
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Science Translational Medicine 8 (326), 326ra321-, 2016-02-17
American Association for the Advancement of Science (AAAS)
