CD8<sup>+</sup>CD28<sup>−</sup> T suppressor cells and the induction of antigen‐specific, antigen‐presenting cell‐mediated suppression of Th reactivity

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書誌事項

公開日
2001-08
権利情報
  • http://onlinelibrary.wiley.com/termsAndConditions#vor
DOI
  • 10.1034/j.1600-065x.2001.1820116.x
公開者
Wiley

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説明

<jats:p><jats:bold>Summary:</jats:bold> Human CD8<jats:sup>+</jats:sup>CD28<jats:sup>−</jats:sup> suppressor T cells (Ts) are a subset of T cells generated in the course of <jats:italic>in vitro</jats:italic> and <jats:italic>in vivo</jats:italic> immunizations. Ts recognize MHC class I:peptide complexes and inhibit the reactivity of T helper cells (Th) with cognate antigen specificity. We have demonstrated for the first time that CD8<jats:sup>+</jats:sup>CD28<jats:sup>−</jats:sup> Ts represent a unique subset of regulatory cells that induces the differentiation of tolerogenic antigen‐presenting cells, initiating a suppressive loop which results in the induction and spreading of Th unresponsiveness.</jats:p>

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