Incentive‐sensitization and addiction

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<jats:p>The question of addiction concerns the process by which drug‐taking behavior, in certain individuals, evolves into compulsive patterns of drug‐seeking and drug‐taking behavior that take place at the expense of most other activities, and the inability to cease drug‐taking, that is, the problem of relapse. In this paper we summarize one view of this process, the "incentive‐sensitization" view, which we first proposed in 1993. Four major tenets of the incentive‐sensitization view are discussed. These are: (1) potentially addictive drugs share the ability to alter brain organization; (2) the brain systems that are altered include those normally involved in the process of incentive motivation and reward; (3) the critical neuroadaptations for addiction render these brain reward systems hypersensitive ("sensitized") to drugs and drug‐associated stimuli; and (4) the brain systems that are sensitized do not mediate the pleasurable or euphoric effects of drugs (drug "liking"), but instead they mediate a subcomponent of reward we have termed incentive salience (drug "wanting").</jats:p>

収録刊行物

  • Addiction

    Addiction 96 (1), 103-114, 2001-01

    Wiley

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