Evaluation of anhydrohexitol nucleic acid, cyclohexenyl nucleic acid and<scp>d</scp>-altritol nucleic acid-modified 2′-O-methyl RNA mixmer antisense oligonucleotides for exon skipping in vitro
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- Bao T. Le
- Centre for Comparative Genomics
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- Suxiang Chen
- Centre for Comparative Genomics
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- Mikhail Abramov
- Laboratory for Medicinal Chemistry
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- Piet Herdewijn
- Laboratory for Medicinal Chemistry
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- Rakesh N. Veedu
- Centre for Comparative Genomics
抄録
<p>We have investigated the potential of anhydrohexitol, cyclohexenyl and altritol nucleic acid-modified antisense oligos in exon skipping, and found that they efficiently induced<italic>Dmd</italic>exon 23 skipping.</p>
収録刊行物
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- Chemical Communications
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Chemical Communications 52 (92), 13467-13470, 2016
Royal Society of Chemistry (RSC)