Construction of PEG-based amphiphilic brush polymers bearing hydrophobic poly(lactic acid) side chains via successive RAFT polymerization and ROP

DOI Web Site 2 Citations
  • Wenhao Qian
    Department of Stomatology
  • Xuemei Song
    Key Laboratory of Synthetic and Self-Assembly Chemistry for Organic Functional Molecules
  • Chun Feng
    Key Laboratory of Synthetic and Self-Assembly Chemistry for Organic Functional Molecules
  • Peicheng Xu
    Department of Stomatology
  • Xue Jiang
    Key Laboratory of Synthetic and Self-Assembly Chemistry for Organic Functional Molecules
  • Yongjun Li
    Key Laboratory of Synthetic and Self-Assembly Chemistry for Organic Functional Molecules
  • Xiaoyu Huang
    Key Laboratory of Synthetic and Self-Assembly Chemistry for Organic Functional Molecules

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Description

<p>This article reports the synthesis of PEG-<italic>b</italic>-(PAA-<italic>g</italic>-PLA) amphiphilic brush polymers by the combination of RAFT polymerization and organocatalytic ROP, which could self-assemble into spheres for sustained release of doxorubicin.</p>

Journal

  • Polymer Chemistry

    Polymer Chemistry 7 (19), 3300-3310, 2016

    Royal Society of Chemistry (RSC)

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