Environmental control programs the emergence of distinct functional ensembles from unconstrained chemical reactions
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- Andrew J. Surman
- WestCHEM, School of Chemistry, University of Glasgow, Glasgow, United Kingdom G12 8QQ;
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- Marc Rodriguez-Garcia
- WestCHEM, School of Chemistry, University of Glasgow, Glasgow, United Kingdom G12 8QQ;
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- Yousef M. Abul-Haija
- WestCHEM, School of Chemistry, University of Glasgow, Glasgow, United Kingdom G12 8QQ;
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- Geoffrey J. T. Cooper
- WestCHEM, School of Chemistry, University of Glasgow, Glasgow, United Kingdom G12 8QQ;
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- Piotr S. Gromski
- WestCHEM, School of Chemistry, University of Glasgow, Glasgow, United Kingdom G12 8QQ;
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- Rebecca Turk-MacLeod
- WestCHEM, School of Chemistry, University of Glasgow, Glasgow, United Kingdom G12 8QQ;
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- Margaret Mullin
- School of Life Sciences, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, United Kingdom G12 8QQ;
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- Cole Mathis
- Beyond Center for Fundamental Concepts in Science, Arizona State University, Tempe, AZ 85287
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- Sara I. Walker
- Beyond Center for Fundamental Concepts in Science, Arizona State University, Tempe, AZ 85287
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- Leroy Cronin
- WestCHEM, School of Chemistry, University of Glasgow, Glasgow, United Kingdom G12 8QQ;
説明
<jats:title>Significance</jats:title> <jats:p>We show that materials with different structure and function can emerge from the same starting materials under different environmental conditions, such as order of reactant addition or inclusion of minerals. The discoveries we report were made possible by using analytical tools more common in omics/systems biology for functional and structural characterization, retasked for exploring and manipulating complex reaction networks. We not only demonstrate that environments can differentiate fixed sets of starting materials (both mixtures of pure amino acids and the classic Miller–Urey “prebiotic soup” model), but that this has functional consequences. It has been often said that biology is “chemistry with history” and this work shows how this process can start.</jats:p>
収録刊行物
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- Proceedings of the National Academy of Sciences
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Proceedings of the National Academy of Sciences 116 (12), 5387-5392, 2019-03-06
Proceedings of the National Academy of Sciences