Beta cells transfer vesicles containing insulin to phagocytes for presentation to T cells
-
- Anthony N. Vomund
- Division of Immunobiology, Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO 63110;
-
- Bernd H. Zinselmeyer
- Division of Immunobiology, Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO 63110;
-
- Jing Hughes
- Division of Immunobiology, Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO 63110;
-
- Boris Calderon
- Division of Immunobiology, Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO 63110;
-
- Carolina Valderrama
- Division of Immunobiology, Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO 63110;
-
- Stephen T. Ferris
- Division of Immunobiology, Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO 63110;
-
- Xiaoxiao Wan
- Division of Immunobiology, Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO 63110;
-
- Kohsuke Kanekura
- Division of Endocrinology, Metabolism and Lipid Research, Department of Internal Medicine, Washington University School of Medicine, St. Louis, MO 63110
-
- Javier A. Carrero
- Division of Immunobiology, Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO 63110;
-
- Fumihiko Urano
- Division of Immunobiology, Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO 63110;
-
- Emil R. Unanue
- Division of Immunobiology, Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO 63110;
書誌事項
- 公開日
- 2015-08-31
- 権利情報
-
- http://www.pnas.org/site/misc/userlicense.xhtml
- DOI
-
- 10.1073/pnas.1515954112
- 公開者
- Proceedings of the National Academy of Sciences
この論文をさがす
説明
<jats:title>Significance</jats:title> <jats:p> This report documents that beta cells from islets of Langerhans normally transfer some of their secretory granules to resident phagocytes. The transfer involves a close contact interaction between live beta cells and phagocytes, increases upon glucose stimulation, and requires mobilization of intracellular Ca <jats:sup>++</jats:sup> . In autoimmune diabetes, the CD4 T cells to various peptides of the insulin B chain recognize the transferred antigens in the phagocytes represented in islets by macrophages and a subset of dendritic cells. We have identified a process whereby antigens become available for recognition by autoreactive T cells in type 1 diabetes. </jats:p>
収録刊行物
-
- Proceedings of the National Academy of Sciences
-
Proceedings of the National Academy of Sciences 112 (40), E5496-, 2015-08-31
Proceedings of the National Academy of Sciences