β‐catenin‐driven binary cell fate decisions in animal development

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  • Vincent Bertrand
    Aix‐Marseille Université, CNRS Institut de Biologie du Développement de Marseille Marseille France

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<jats:p>The Wnt/β‐catenin pathway plays key roles during animal development. In several species, β‐catenin is used in a reiterative manner to regulate cell fate diversification between daughter cells following division. This binary cell fate specification mechanism has been observed in animals that belong to very diverse phyla: the nematode <jats:italic>Caenorhabditis elegans</jats:italic>, the annelid <jats:italic>Platynereis</jats:italic>, and the ascidian <jats:italic>Ciona</jats:italic>. It may also play a role in the regulation of several stem cell lineages in vertebrates. While the molecular mechanism behind this binary cell fate switch is not fully understood, it appears that both secreted Wnt ligands and asymmetric cortical factors contribute to the generation of the difference in nuclear β‐catenin levels between daughter cells. β‐Catenin then cooperates with lineage specific transcription factors to induce the expression of novel sets of transcription factors at each round of divisions, thereby diversifying cell fate. <jats:italic>WIREs Dev Biol</jats:italic> 2016, 5:377–388. doi: 10.1002/wdev.228</jats:p><jats:p>This article is categorized under: <jats:list list-type="explicit-label"> <jats:list-item><jats:p>Gene Expression and Transcriptional Hierarchies > Regulatory Mechanisms</jats:p></jats:list-item> <jats:list-item><jats:p>Signaling Pathways > Cell Fate Signaling</jats:p></jats:list-item> <jats:list-item><jats:p>Invertebrate Organogenesis > Worms</jats:p></jats:list-item> </jats:list></jats:p>

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