Effect of poly(ethylene glycol) molecular weight on tensile and swelling properties of oligo(poly(ethylene glycol) fumarate) hydrogels for cartilage tissue engineering

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書誌事項

公開日
2001-11-15
権利情報
  • http://onlinelibrary.wiley.com/termsAndConditions#vor
DOI
  • 10.1002/jbm.1259
公開者
Wiley

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<jats:title>Abstract</jats:title><jats:p>This study was designed to determine the effect of changes in poly(ethylene glycol) (PEG) molecular weight on swelling and mechanical properties of hydrogels made from a novel polymer, oligo(poly(ethylene glycol) fumarate) (OPF), recently developed in our laboratory. Properties of hydrogels made from OPF with initial PEG molecular weights of 860, 3900, and 9300 were examined. The PEG 3900 formulation had a tensile modulus of 23.1 ± 12.4 kPa and percent elongation at fracture of 53.2 ± 13.7%; the PEG 9300 formulation had similar tensile properties (modulus: 16.5 ± 4.6 kPa, elongation: 76.0 ± 26.4%). However, the PEG 860 gels had a significantly higher modulus (89.5 ± 50.7 kPa) and a significantly smaller percent elongation at fracture (30.1 ± 6.4%), when compared with other formulations. Additionally, there were significant differences in percent swelling between each of the formulations. Molecular weight between crosslinks (<jats:italic>M</jats:italic><jats:sub>c</jats:sub>) and mesh size were calculated for each OPF formulation. <jats:italic>M</jats:italic><jats:sub>c</jats:sub> increased from 2010 ± 116 g/mol with PEG 860 to 6250 ± 280 g/mol with PEG 9300. Mesh size calculations showed a similar trend (76 ± 2 Å for PEG 860 to 160 ± 6 Å for PEG 9300). It was also found that these hydrogels could be laminated if a second layer was added before the first had completely crosslinked. Mechanical testing of these laminated gels revealed that the presence of an interfacial area did not significantly alter their tensile properties. These results suggest that the material properties of OPF‐based hydrogels can be altered by changing the molecular weight of PEG used in synthesis and that multilayered OPF hydrogel constructs can be produced, with each layer having distinct mechanical properties. © 2001 Wiley Periodicals, Inc. J Biomed Mater Res 59: 429–437, 2002</jats:p>

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