<i>Drosophila</i> neuropeptide F mediates integration of chemosensory stimulation and conditioning of the nervous system by food

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<jats:title>Abstract</jats:title><jats:p>The conserved neuropeptide Y (NPY) signaling pathway has been strongly implicated in the stimulation of food uptake in vertebrates as well as in the regulation of food conditioned foraging behaviors of <jats:italic>Caenorhabditis elegans</jats:italic>. Using <jats:italic>in situ</jats:italic> RNA hybridization and immunocytochemistry, we report the neuronal network of <jats:italic>Drosophila</jats:italic> neuropeptide F (dNPF), a human NPY homologue, in the larval central nervous system and its food‐dependent modifications. We provide indications that gustatory stimulation by sugar, but not its ingestion or metabolism, is sufficient to trigger long‐term, dose‐dependent alterations of the dNPF neuronal circuit through both <jats:italic>dnpf</jats:italic> activation and increased synaptic transmission. Our results strongly suggest that the dNPF neuronal circuit is an integral part of the sensory system that mediates food signaling, providing the neural basis for understanding how invertebrate NPY regulates food response. © 2001 John Wiley & Sons, Inc. J Neurobiol 47: 16–25, 2001</jats:p>

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