Breakdown of Cortical Effective Connectivity During Sleep

DOI Web Site 被引用文献36件
  • Marcello Massimini
    Department of Psychiatry, University of Wisconsin, Madison, 6001 Research Park Boulevard, Madison, WI 53719, USA.
  • Fabio Ferrarelli
    Department of Psychiatry, University of Wisconsin, Madison, 6001 Research Park Boulevard, Madison, WI 53719, USA.
  • Reto Huber
    Department of Psychiatry, University of Wisconsin, Madison, 6001 Research Park Boulevard, Madison, WI 53719, USA.
  • Steve K. Esser
    Department of Psychiatry, University of Wisconsin, Madison, 6001 Research Park Boulevard, Madison, WI 53719, USA.
  • Harpreet Singh
    Department of Psychiatry, University of Wisconsin, Madison, 6001 Research Park Boulevard, Madison, WI 53719, USA.
  • Giulio Tononi
    Department of Psychiatry, University of Wisconsin, Madison, 6001 Research Park Boulevard, Madison, WI 53719, USA.

書誌事項

公開日
2005-09-30
DOI
  • 10.1126/science.1117256
公開者
American Association for the Advancement of Science (AAAS)

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説明

<jats:p>When we fall asleep, consciousness fades yet the brain remains active. Why is this so? To investigate whether changes in cortical information transmission play a role, we used transcranial magnetic stimulation together with high-density electroencephalography and asked how the activation of one cortical area (the premotor area) is transmitted to the rest of the brain. During quiet wakefulness, an initial response (∼15 milliseconds) at the stimulation site was followed by a sequence of waves that moved to connected cortical areas several centimeters away. During non–rapid eye movement sleep, the initial response was stronger but was rapidly extinguished and did not propagate beyond the stimulation site. Thus, the fading of consciousness during certain stages of sleep may be related to a breakdown in cortical effective connectivity.</jats:p>

収録刊行物

  • Science

    Science 309 (5744), 2228-2232, 2005-09-30

    American Association for the Advancement of Science (AAAS)

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