Skin-resident memory CD8 <sup>+</sup> T cells trigger a state of tissue-wide pathogen alert
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- Silvia Ariotti
- Division of Immunology, Netherlands Cancer Institute, 1066 CX Amsterdam, Netherlands.
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- Marc A. Hogenbirk
- Division of Biological Stress Response, Netherlands Cancer Institute, 1066 CX Amsterdam, Netherlands.
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- Feline E. Dijkgraaf
- Division of Immunology, Netherlands Cancer Institute, 1066 CX Amsterdam, Netherlands.
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- Lindy L. Visser
- Division of Immunology, Netherlands Cancer Institute, 1066 CX Amsterdam, Netherlands.
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- Mirjam E. Hoekstra
- Division of Immunology, Netherlands Cancer Institute, 1066 CX Amsterdam, Netherlands.
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- Ji-Ying Song
- Experimental Animal Pathology, Netherlands Cancer Institute, 1066 CX Amsterdam, Netherlands.
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- Heinz Jacobs
- Division of Biological Stress Response, Netherlands Cancer Institute, 1066 CX Amsterdam, Netherlands.
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- John B. Haanen
- Division of Immunology, Netherlands Cancer Institute, 1066 CX Amsterdam, Netherlands.
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- Ton N. Schumacher
- Division of Immunology, Netherlands Cancer Institute, 1066 CX Amsterdam, Netherlands.
抄録
<jats:title>Resident memory T cells sound the alarm</jats:title> <jats:p> Immunological memory protects against reinfection. Resident memory T cells (T <jats:sub>RM</jats:sub> ) are long-lived and remain in the tissues where they first encountered a pathogen (see the Perspective by Carbone and Gebhardt). Schenkel <jats:italic>et al.</jats:italic> and Ariotti <jats:italic>et al.</jats:italic> found that CD8 <jats:sup>+</jats:sup> T <jats:sub>RM</jats:sub> cells act like first responders in the female reproductive tissue or the skin of mice upon antigen reencounter. By secreting inflammatory proteins, T <jats:sub>RM</jats:sub> cells rapidly activated local immune cells to respond, so much so that they protected against infection with an unrelated pathogen. Iijima and Iwasaki found that CD4 <jats:sup>+</jats:sup> T <jats:sub>RM</jats:sub> cells protected mice against reinfection with intravaginal herpes simplex virus 2. </jats:p> <jats:p> <jats:italic>Science</jats:italic> , this issue p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6205" page="98" related-article-type="in-this-issue" vol="346" xlink:href="10.1126/science.1254536">98</jats:related-article> , p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6205" page="101" related-article-type="in-this-issue" vol="346" xlink:href="10.1126/science.1254803">101</jats:related-article> , p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6205" page="93" related-article-type="in-this-issue" vol="346" xlink:href="10.1126/science.1257530">93</jats:related-article> ; see also p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6205" page="40" related-article-type="in-this-issue" vol="346" xlink:href="10.1126/science.1259925">40</jats:related-article> </jats:p>
収録刊行物
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- Science
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Science 346 (6205), 101-105, 2014-10-03
American Association for the Advancement of Science (AAAS)