Localization, Secretion, and Action of Inhibin in Human Placenta

DOI Web Site 被引用文献3件
  • Felice Petraglia
    The Clayton Foundation Laboratories for Peptide Biology, The Salk Institute, La Jolla, CA 92037.
  • Paul Sawchenko
    Developmental Neurobiology Laboratory, The Salk Institute, La Jolla, CA 92037.
  • Alan T. W. Lim
    The Clayton Foundation Laboratories for Peptide Biology, The Salk Institute, La Jolla, CA 92037.
  • Jean Rivier
    The Clayton Foundation Laboratories for Peptide Biology, The Salk Institute, La Jolla, CA 92037.
  • Wylie Vale
    The Clayton Foundation Laboratories for Peptide Biology, The Salk Institute, La Jolla, CA 92037.

書誌事項

公開日
1987-07-10
DOI
  • 10.1126/science.3299703
公開者
American Association for the Advancement of Science (AAAS)

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説明

<jats:p>Inhibin is a gonadal glycoprotein hormone that regulates the production of follicle-stimulating hormone (FSH) by the anterior pituitary gland and exhibits intragonadal actions as well. The present study shows that inhibin-like immunoreactivity (inhibin-LI) is present in cells of the cytotrophoblast layer of human placenta at term and in primary cultures of human trophoblasts. Human chorionic gonadotropin (hCG) stimulated secretion of inhibin-LI from these cultured placental cells. This effect was mimicked by 8-bromo-cyclic adenosine monophosphate (8-bromo-cAMP), forskolin, and cholera toxin, suggesting that the mechanism of hCG induction of placental inhibin-LI secretion is cAMP-dependent. Incubation with an antiserum that binds the α-subunit of human inhibin increased the secretion of hCG and gonadotropin-releasing hormone-like immunoreactivity (GnRH-LI) from trophoblast cells in culture, suggesting a local tonic inhibitory action of endogenous inhibin on hCG and GnRH-LI release. The action of inhibin on hCG secretion may partially require the presence of placental GnRH, as suggested by evidence that a synthetic GnRH antagonist partially reverses the hCG increase induced by inhibin immunoneutralization. Results suggest paracrine roles for both inhibin and GnRH in the regulation of placental hCG production.</jats:p>

収録刊行物

  • Science

    Science 237 (4811), 187-189, 1987-07-10

    American Association for the Advancement of Science (AAAS)

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