p16 INK4a andp15INK4b gene methylations in plasma cells from monoclonal gammopathy of undetermined significance

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  • Gaëlle Guillerm
    From the Unité Institut National de la Santé et de la Recherche Médicale 524, Institut de Recherche sur le Cancer de Lille (IRCL), and the Service des Maladies du Sang, Centre Hospitalier et Universitaire (CHU) Lille, Lille, France; the Department of Hematology, Wroclaw Medical University, Wroclaw, Poland; and the Laboratoire d'Hématologie, CHU Nantes, Nantes, France.
  • Emmanuel Gyan
    From the Unité Institut National de la Santé et de la Recherche Médicale 524, Institut de Recherche sur le Cancer de Lille (IRCL), and the Service des Maladies du Sang, Centre Hospitalier et Universitaire (CHU) Lille, Lille, France; the Department of Hematology, Wroclaw Medical University, Wroclaw, Poland; and the Laboratoire d'Hématologie, CHU Nantes, Nantes, France.
  • Darius Wolowiec
    From the Unité Institut National de la Santé et de la Recherche Médicale 524, Institut de Recherche sur le Cancer de Lille (IRCL), and the Service des Maladies du Sang, Centre Hospitalier et Universitaire (CHU) Lille, Lille, France; the Department of Hematology, Wroclaw Medical University, Wroclaw, Poland; and the Laboratoire d'Hématologie, CHU Nantes, Nantes, France.
  • Thierry Facon
    From the Unité Institut National de la Santé et de la Recherche Médicale 524, Institut de Recherche sur le Cancer de Lille (IRCL), and the Service des Maladies du Sang, Centre Hospitalier et Universitaire (CHU) Lille, Lille, France; the Department of Hematology, Wroclaw Medical University, Wroclaw, Poland; and the Laboratoire d'Hématologie, CHU Nantes, Nantes, France.
  • Hervé Avet-Loiseau
    From the Unité Institut National de la Santé et de la Recherche Médicale 524, Institut de Recherche sur le Cancer de Lille (IRCL), and the Service des Maladies du Sang, Centre Hospitalier et Universitaire (CHU) Lille, Lille, France; the Department of Hematology, Wroclaw Medical University, Wroclaw, Poland; and the Laboratoire d'Hématologie, CHU Nantes, Nantes, France.
  • Kazimierz Kuliczkowski
    From the Unité Institut National de la Santé et de la Recherche Médicale 524, Institut de Recherche sur le Cancer de Lille (IRCL), and the Service des Maladies du Sang, Centre Hospitalier et Universitaire (CHU) Lille, Lille, France; the Department of Hematology, Wroclaw Medical University, Wroclaw, Poland; and the Laboratoire d'Hématologie, CHU Nantes, Nantes, France.
  • Francis Bauters
    From the Unité Institut National de la Santé et de la Recherche Médicale 524, Institut de Recherche sur le Cancer de Lille (IRCL), and the Service des Maladies du Sang, Centre Hospitalier et Universitaire (CHU) Lille, Lille, France; the Department of Hematology, Wroclaw Medical University, Wroclaw, Poland; and the Laboratoire d'Hématologie, CHU Nantes, Nantes, France.
  • Pierre Fenaux
    From the Unité Institut National de la Santé et de la Recherche Médicale 524, Institut de Recherche sur le Cancer de Lille (IRCL), and the Service des Maladies du Sang, Centre Hospitalier et Universitaire (CHU) Lille, Lille, France; the Department of Hematology, Wroclaw Medical University, Wroclaw, Poland; and the Laboratoire d'Hématologie, CHU Nantes, Nantes, France.
  • Bruno Quesnel
    From the Unité Institut National de la Santé et de la Recherche Médicale 524, Institut de Recherche sur le Cancer de Lille (IRCL), and the Service des Maladies du Sang, Centre Hospitalier et Universitaire (CHU) Lille, Lille, France; the Department of Hematology, Wroclaw Medical University, Wroclaw, Poland; and the Laboratoire d'Hématologie, CHU Nantes, Nantes, France.

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<jats:title>Abstract</jats:title> <jats:p>p15INK4b and p16INK4a proteins are cell cycle regulators involved in the inhibition of G1 phase progression. High frequency of methylation of both genes has been reported in multiple myeloma (MM), but it remains to be determined how and when these alterations contribute to tumorigenesis. Monoclonal gammopathy of undetermined significance (MGUS) represents an early disease stage in a fraction of MMs. Plasma cells from 33 patients with MGUS and 33 patients with MM were isolated and analyzed forp15INK4b and p16INK4amethylation by methylation-specific polymerase chain reaction. Selective methylation was found in 19% forp16INK4a, 36% forp15INK4b, and 6.5% for both genes in MGUS, and frequencies were similar in MM suggesting that methylation of these genes is an early event, not associated with transition from MGUS to MM. p15INK4b andp16INK4a gene methylation might contribute to immortalization of plasma cells rather than malignant transformation in the natural history of MM.</jats:p>

収録刊行物

  • Blood

    Blood 98 (1), 244-246, 2001-07-01

    American Society of Hematology

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