Japanese guidelines for the management of acute pancreatitis: Japanese Guidelines 2015

  • Masamichi Yokoe
    General Internal Medicine Japanese Red Cross Nagoya Daini Hospital Nagoya Japan
  • Tadahiro Takada
    Department of Surgery Teikyo University School of Medicine Tokyo Japan
  • Toshihiko Mayumi
    Department of Emergency Medicine, School of Medicine University of Occupational and Environmental Health KitaKyushu Japan
  • Masahiro Yoshida
    Department of Hemodialysis and Surgery, Chemotherapy Research Institute International University of Health and Welfare Ichikawa Japan
  • Shuji Isaji
    Hepatobiliary Pancreatic & Transplant Surgery Mie University Graduate School of Medicine Mie Japan
  • Keita Wada
    Department of Surgery Teikyo University School of Medicine Tokyo Japan
  • Takao Itoi
    Department of Gastroenterology and Hepatology Tokyo Medical University Tokyo Japan
  • Naohiro Sata
    Department of Surgery Jichi Medical University Shimotsuke Tochigi Japan
  • Toshifumi Gabata
    Department of Radiology Kanazawa University, School of Medical Science Kanazawa Japan
  • Hisato Igarashi
    Clinical Education Center Kyushu University Hospital Fukuoka Japan
  • Keisho Kataoka
    Otsu Municipal Hospital Shiga
  • Masahiko Hirota
    Department of Surgery Kumamoto Regional Medical Center Kumamoto Japan
  • Masumi Kadoya
    Department of Radiology Shinshu University School of Medicine Matsumoto Japan
  • Nobuya Kitamura
    Department of Emergency and Critical Care Medicine Kimitsu Chuo Hospital Kisarazu Chiba Japan
  • Yasutoshi Kimura
    Department of Surgery Surgical Oncology and Science, Sapporo Medical University Sapporo Japan
  • Seiki Kiriyama
    Department of Gastroenterology Ogaki Municipal Hospital Ogaki Japan
  • Kunihiro Shirai
    Department of Emergency and Critical Care Medicine Ichinomiya Municipal Hospital Ichinomiya Japan
  • Takayuki Hattori
    Department of Radiology, Tokyo Metropolitan Health and Medical Treatment Corporation Ohkubo Hospital Tokyo Japan
  • Kazunori Takeda
    Department of Surgery National Hospital Organization Sendai Medical Center Sendai Japan
  • Yoshifumi Takeyama
    Department of Surgery Kinki University Faculty of Medicine Osaka Japan
  • Morihisa Hirota
    Division of Gastroenterology Tohoku University Graduate School of Medicine Sendai Japan
  • Miho Sekimoto
    The University of Tokyo Graduate School of Public Policy Health Policy Unit Tokyo
  • Satoru Shikata
    Department of Family Medicine Mie Prefectural Ichishi Hospital Mie Japan
  • Shinju Arata
    Gastroenterological Center Yokohama City University Medical Center Yokohama Japan
  • Koichi Hirata
    Department of Surgery Surgical Oncology and Science, Sapporo Medical University Sapporo Japan

抄録

<jats:title>Abstract</jats:title><jats:sec><jats:title>Background</jats:title><jats:p>Japanese (JPN) guidelines for the management of acute pancreatitis were published in 2006. The severity assessment criteria for acute pancreatitis were later revised by the Japanese Ministry of Health, Labour and Welfare (MHLW) in 2008, leading to their publication as the JPN Guidelines 2010. Following the 2012 revision of the Atlanta Classifications of Acute Pancreatitis, in which the classifications of regional complications of pancreatitis were revised, the development of a minimally invasive method for local complications of pancreatitis spread, and emerging evidence was gathered and revised into the JPN Guidelines.</jats:p></jats:sec><jats:sec><jats:title>Methods</jats:title><jats:p>A comprehensive evaluation was carried out on the evidence for epidemiology, diagnosis, severity, treatment, post‐endoscopic retrograde cholangiopancreatography (ERCP) pancreatitis and clinical indicators, based on the concepts of the GRADE system (Grading of Recommendations Assessment, Development and Evaluation). With the graded recommendations, where the evidence was unclear, Meta‐Analysis team for JPN Guidelines 2015 conducted an additional new meta‐analysis, the results of which were included in the guidelines.</jats:p></jats:sec><jats:sec><jats:title>Results</jats:title><jats:p>Thirty‐nine questions were prepared in 17 subject areas, for which 43 recommendations were made. The 17 subject areas were: Diagnosis, Diagnostic imaging, Etiology, Severity assessment, Transfer indication, Fluid therapy, Nasogastric tube, Pain control, Antibiotics prophylaxis, Protease inhibitor, Nutritional support, Intensive care, management of Biliary Pancreatitis, management of Abdominal Compartment Syndrome, Interventions for the local complications, Post‐ERCP pancreatitis and Clinical Indicator (Pancreatitis Bundles 2015). Meta‐analysis was conducted in the following four subject areas based on randomized controlled trials: (1) prophylactic antibiotics use; (2) prophylactic pancreatic stent placement for the prevention of post‐ERCP pancreatitis; (3) prophylactic non‐steroidal anti‐inflammatory drugs (NSAIDs) for the prevention of post‐ERCP pancreatitis; and (4) peritoneal lavage. Using the results of the meta‐analysis, recommendations were graded to create useful information. In addition, a mobile application was developed, which made it possible to diagnose, assess severity and check pancreatitis bundles.</jats:p></jats:sec><jats:sec><jats:title>Conclusions</jats:title><jats:p>The JPN Guidelines 2015 were prepared using the most up‐to‐date methods, and including the latest recommended medical treatments, and we are confident that this will make them easy for many clinicians to use, and will provide a useful tool in the decision‐making process for the treatment of patients, and optimal medical support. The free mobile application and calculator for the JPN Guidelines 2015 is available via <jats:ext-link xmlns:xlink="http://www.w3.org/1999/xlink" xlink:href="http://www.jshbps.jp/en/guideline/jpn-guideline2015.html">http://www.jshbps.jp/en/guideline/jpn‐guideline2015.html</jats:ext-link></jats:p></jats:sec>

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