Me3SiCl/HMPA accelerated conjugate addition of catalytic copper reagent. Stereoselective synthesis of enol silyl ether of aldehyde

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Abstract Copper-catalyzed conjugate addition of the Grignard reagents in the presence of Me 3 SiCl and HMPA proceeds in much higher yield than the reaction of conventional organocopper reagents and shows very good regio-, stereo-, and chemoselectivities.

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