Natural compounds as potential adjuvants to cancer therapy: Preclinical evidence

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  • Shian‐Ren Lin
    Department of Life Science and Institute of Biotechnology National Dong Hwa University Hualien Taiwan
  • Chia‐Hsiang Chang
    Department of Life Science and Institute of Biotechnology National Dong Hwa University Hualien Taiwan
  • Che‐Fang Hsu
    Department of Life Science and Institute of Biotechnology National Dong Hwa University Hualien Taiwan
  • May‐Jwan Tsai
    Neural Regeneration Laboratory, Neurological Institute Taipei Veterans General Hospital Taipei City Taiwan
  • Henrich Cheng
    Neural Regeneration Laboratory, Neurological Institute Taipei Veterans General Hospital Taipei City Taiwan
  • Max K. Leong
    Department of Chemistry National Dong Hwa University Hualien Taiwan
  • Ping‐Jyun Sung
    Graduate Institute of Marine Biotechnology National Dong Hwa University Pingtung Taiwan
  • Jian‐Chyi Chen
    Department of Biotechnology Southern Taiwan University of Science and Technology Tainan City Taiwan
  • Ching‐Feng Weng
    Graduate Institute of Marine Biotechnology National Dong Hwa University Pingtung Taiwan

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<jats:sec><jats:label /><jats:p>Traditional chemotherapy is being considered due to hindrances caused by systemic toxicity. Currently, the administration of multiple chemotherapeutic drugs with different biochemical/molecular targets, known as combination chemotherapy, has attained numerous benefits like efficacy enhancement and amelioration of adverse effects that has been broadly applied to various cancer types. Additionally, seeking natural‐based alternatives with less toxicity has become more important. Experimental evidence suggests that herbal extracts such as <jats:styled-content style="fixed-case"><jats:italic>Solanum nigrum</jats:italic></jats:styled-content> and <jats:italic>Claviceps purpurea</jats:italic> and isolated herbal compounds (e.g., curcumin, resveratrol, and matairesinol) combined with antitumoral drugs have the potential to attenuate resistance against cancer therapy and to exert chemoprotective actions. Plant products are not free of risks: Herb adverse effects, including herb–drug interactions, should be carefully considered.</jats:p></jats:sec><jats:sec><jats:title>Linked Articles</jats:title><jats:p>This article is part of a themed section on The Pharmacology of Nutraceuticals. To view the other articles in this section visit <jats:ext-link xmlns:xlink="http://www.w3.org/1999/xlink" xlink:href="http://onlinelibrary.wiley.com/doi/10.1111/bph.v177.6/issuetoc">http://onlinelibrary.wiley.com/doi/10.1111/bph.v177.6/issuetoc</jats:ext-link></jats:p></jats:sec>

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