Identification of a novel member of the T1R family of putative taste receptors

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Abstract

<jats:p>In the gustatory system, the recognition of sugars, amino acids and bitter‐tasting compounds is the function of specialized G protein‐coupled receptors. Recently, two members of novel subfamily of G protein‐coupled receptors were proposed to function as taste receptors based on their specific expression in taste receptor cells. Here, we report the identification of a third member, T1R3, of this family of receptors. <jats:italic>T1R3</jats:italic> maps near the telomere of mouse chromosome 4 rendering it a candidate for the <jats:italic>Sac</jats:italic> locus, a primary determinant of sweet preference in mice. Consistent with its candidacy for the <jats:italic>Sac</jats:italic> locus, <jats:italic>T1R3</jats:italic> displays taste receptor cell‐specific expression. In addition, taster and non‐taster strains of mouse harbor different alleles of <jats:italic>T1R3</jats:italic>.</jats:p>

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