Mixed-effects association of single cells identifies an expanded effector CD4<sup>+</sup>T cell subset in rheumatoid arthritis

DOI Web Site Web Site 7 Citations
  • Chamith Y. Fonseka
    Center for Data Sciences, Brigham and Women’s Hospital and Harvard Medical School, Boston, MA 02115, USA.
  • Deepak A. Rao
    Division of Rheumatology, Immunology, and Allergy, Brigham and Women’s Hospital and Harvard Medical School, Boston, MA 02115, USA.
  • Nikola C. Teslovich
    Division of Rheumatology, Immunology, and Allergy, Brigham and Women’s Hospital and Harvard Medical School, Boston, MA 02115, USA.
  • Ilya Korsunsky
    Center for Data Sciences, Brigham and Women’s Hospital and Harvard Medical School, Boston, MA 02115, USA.
  • Susan K. Hannes
    Division of Rheumatology, Immunology, and Allergy, Brigham and Women’s Hospital and Harvard Medical School, Boston, MA 02115, USA.
  • Kamil Slowikowski
    Center for Data Sciences, Brigham and Women’s Hospital and Harvard Medical School, Boston, MA 02115, USA.
  • Michael F. Gurish
    Division of Rheumatology, Immunology, and Allergy, Brigham and Women’s Hospital and Harvard Medical School, Boston, MA 02115, USA.
  • Laura T. Donlin
    Arthritis and Tissue Degeneration Program, Hospital for Special Surgery, New York, NY 10021, USA.
  • James A. Lederer
    Center for Data Sciences, Brigham and Women’s Hospital and Harvard Medical School, Boston, MA 02115, USA.
  • Michael E. Weinblatt
    Division of Rheumatology, Immunology, and Allergy, Brigham and Women’s Hospital and Harvard Medical School, Boston, MA 02115, USA.
  • Elena M. Massarotti
    Division of Rheumatology, Immunology, and Allergy, Brigham and Women’s Hospital and Harvard Medical School, Boston, MA 02115, USA.
  • Jonathan S. Coblyn
    Division of Rheumatology, Immunology, and Allergy, Brigham and Women’s Hospital and Harvard Medical School, Boston, MA 02115, USA.
  • Simon M. Helfgott
    Division of Rheumatology, Immunology, and Allergy, Brigham and Women’s Hospital and Harvard Medical School, Boston, MA 02115, USA.
  • Derrick J. Todd
    Division of Rheumatology, Immunology, and Allergy, Brigham and Women’s Hospital and Harvard Medical School, Boston, MA 02115, USA.
  • Vivian P. Bykerk
    Department of Medicine, Weill Cornell Medical College, Cornell University, New York, NY 10021, USA.
  • Elizabeth W. Karlson
    Division of Rheumatology, Immunology, and Allergy, Brigham and Women’s Hospital and Harvard Medical School, Boston, MA 02115, USA.
  • Joerg Ermann
    Division of Rheumatology, Immunology, and Allergy, Brigham and Women’s Hospital and Harvard Medical School, Boston, MA 02115, USA.
  • Yvonne C. Lee
    Division of Rheumatology, Immunology, and Allergy, Brigham and Women’s Hospital and Harvard Medical School, Boston, MA 02115, USA.
  • Michael B. Brenner
    Division of Rheumatology, Immunology, and Allergy, Brigham and Women’s Hospital and Harvard Medical School, Boston, MA 02115, USA.
  • Soumya Raychaudhuri
    Center for Data Sciences, Brigham and Women’s Hospital and Harvard Medical School, Boston, MA 02115, USA.

Search this article

Description

<jats:p>Mixed-effects regression of single-cell data accounts for confounding variation and reveals an expanded CD4<jats:sup>+</jats:sup>T cell population in rheumatoid arthritis.</jats:p>

Journal

  • Science Translational Medicine

    Science Translational Medicine 10 (463), eaaq0305-, 2018-10-17

    American Association for the Advancement of Science (AAAS)

Citations (7)*help

See more

Report a problem

Back to top