IgA Nephropathy

  • Jennifer C. Rodrigues
    Department of Medicine, University of Toronto and Division of Nephrology, University Health Network, Toronto, Ontario, Canada;
  • Mark Haas
    Department of Pathology and Laboratory Medicine, Cedars-Sinai Medical Center, Los Angeles, California; and
  • Heather N. Reich
    Department of Medicine, University of Toronto and Division of Nephrology, University Health Network, Toronto, Ontario, Canada;

説明

<jats:p>IgA nephropathy (IgAN) is a leading cause of CKD and renal failure. Recent international collaborative efforts have led to important discoveries that have improved our understanding of some of the key steps involved in the immunopathogenesis of IgAN. Furthermore, establishment of multicenter networks has contributed to rigorous design and execution of clinical trials that have provided important insights regarding immunotherapy in IgAN. In this article, we review emerging developments in clinical and translational IgAN research and describe how these novel findings will influence future strategies to improve the outcome of patients with IgAN.</jats:p>

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