Effect of age and <i>Helicobacter pylori</i> infection on gastric acid secretion
説明
<jats:title>Abstract</jats:title><jats:p> <jats:bold> <jats:italic>Background</jats:italic> </jats:bold>: Whether gastric acid secretion decreases with age is still controversial. With the discovery of <jats:italic>Helicobacter pylori</jats:italic>, the association of this bacterium with gastric acid secretion has also been discussed. The aim of this study was to investigate the relationship between gastric acid secretion, age and <jats:italic>H. pylori</jats:italic> infection.</jats:p><jats:p> <jats:bold> <jats:italic>Methods</jats:italic> </jats:bold>: The presence of <jats:italic>H. pylori</jats:italic> infection, the grade of fundic atrophic gastritis (FAG), and gastric acid secretion were investigated in 280 subjects without localized lesions in the upper gastrointestinal tract. <jats:italic>Helicobacter pylori</jats:italic> infection was confirmed by Giemsa and immunohistochemical staining, and FAG of biopsy specimens was graded on a scale of 0–4.</jats:p><jats:p> <jats:bold> <jats:italic>Results</jats:italic> </jats:bold>: Both basal and maximal acid output decreased with age in <jats:italic>H. pylori</jats:italic>‐positive subjects, while they did not change with age in <jats:italic>H. pylori</jats:italic>‐negative subjects. Gastric acid secretion decreased with the progression of FAG. An age‐correlated decrease in gastric acid secretion in <jats:italic>H. pylori</jats:italic>‐positive subjects depended on an increasing prevalence of FAG with age.</jats:p><jats:p> <jats:bold> <jats:italic>Conclusions</jats:italic> </jats:bold>: In the population studied, advancing age had no influence on gastric acid secretion in <jats:italic>H. pylori</jats:italic>‐negative subjects. Gastric acid secretion decreases with age in <jats:italic>H. pylori</jats:italic>‐positive subjects because of the increasing prevalence of FAG with age.</jats:p><jats:p>© 2000 Blackwell Science Asia Pty Ltd</jats:p>
収録刊行物
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- Journal of Gastroenterology and Hepatology
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Journal of Gastroenterology and Hepatology 15 (3), 277-283, 2000-03-10
Wiley