Invited review: Frontotemporal dementia caused by <i>microtubule‐associated protein tau</i> gene (<scp><i>MAPT</i></scp>) mutations: a chameleon for neuropathology and neuroimaging
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- Bernardino Ghetti
- Department of Pathology and Laboratory Medicine Indiana University School of Medicine Indianapolis USA
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- Adrian L. Oblak
- Department of Pathology and Laboratory Medicine Indiana University School of Medicine Indianapolis USA
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- Bradley F. Boeve
- Department of Neurology Mayo Clinic Rochester USA
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- Keith A. Johnson
- Department of Radiology Massachusetts General Hospital and Harvard Medical School Boston USA
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- Bradford C. Dickerson
- Department of Neurology Massachusetts General Hospital and Harvard Medical School Boston USA
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- Michel Goedert
- Medical Research Council Laboratory of Molecular Biology Cambridge UK
書誌事項
- 公開日
- 2015-01-29
- 権利情報
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- http://creativecommons.org/licenses/by/4.0/
- DOI
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- 10.1111/nan.12213
- 公開者
- Wiley
この論文をさがす
説明
<jats:p>Hereditary frontotemporal dementia associated with mutations in the <jats:italic>microtubule‐associated protein tau</jats:italic> gene (<jats:styled-content style="fixed-case"><jats:italic>MAPT</jats:italic></jats:styled-content>) is a protean disorder. Three neuropathologic subtypes can be recognized, based on the presence of inclusions made of tau isoforms with three and four repeats, predominantly three repeats and mostly four repeats. This is relevant for establishing a correlation between structural magnetic resonance imaging and positron emission tomography using tracers specific for aggregated tau. Longitudinal studies will be essential to determine the evolution of anatomical alterations from the asymptomatic stage to the various phases of disease following the onset of symptoms.</jats:p>
収録刊行物
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- Neuropathology and Applied Neurobiology
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Neuropathology and Applied Neurobiology 41 (1), 24-46, 2015-01-29
Wiley