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- Gregg L. Semenza
- Institute of Genetic Medicine, Departments of Pediatrics and Medicine, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21287-3914
説明
<jats:p>All organisms can sense O<jats:sub>2</jats:sub>concentration and respond to hypoxia with adaptive changes in gene expression. The large body size of mammals necessitates the development of multiple complex physiological systems to ensure adequate O<jats:sub>2</jats:sub>delivery to all cells under normal conditions. The transcriptional regulator hypoxia-inducible factor 1 (HIF-1) is an essential mediator of O<jats:sub>2</jats:sub>homeostasis. HIF-1 is required for the establishment of key physiological systems during development and their subsequent utilization in fetal and postnatal life. HIF-1 also appears to play a key role in the pathophysiology of cancer, cardiovascular disease, and chronic lung disease, which represent the major causes of mortality among industrialized societies. Genetic or pharmacological modulation of HIF-1 activity in vivo may represent a novel therapeutic approach to these disorders.</jats:p>
収録刊行物
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- Journal of Applied Physiology
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Journal of Applied Physiology 88 (4), 1474-1480, 2000-04-01
American Physiological Society
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詳細情報 詳細情報について
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- CRID
- 1360574095363060992
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- ISSN
- 15221601
- 87507587
- http://id.crossref.org/issn/87507587
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- データソース種別
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- Crossref