Epithelial<i>Bmpr1a</i>regulates differentiation and proliferation in postnatal hair follicles and is essential for tooth development

DOI PDF 被引用文献18件
  • Thomas Andl
    Department of Dermatology, University of Pennsylvania Medical School,Philadelphia, PA 19104, USA
  • Kyung Ahn
    Center for Childhood Communication, Abramson Research Center, The Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA
  • Alladin Kairo
    Department of Dermatology, University of Pennsylvania Medical School,Philadelphia, PA 19104, USA
  • Emily Y. Chu
    Department of Dermatology, University of Pennsylvania Medical School,Philadelphia, PA 19104, USA
  • Lara Wine-Lee
    Center for Childhood Communication, Abramson Research Center, The Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA
  • Seshamma T. Reddy
    Department of Dermatology, University of Pennsylvania Medical School,Philadelphia, PA 19104, USA
  • Nirvana J. Croft
    Department of Dermatology, University of Pennsylvania Medical School,Philadelphia, PA 19104, USA
  • Judith A. Cebra-Thomas
    Department of Dermatology, University of Pennsylvania Medical School,Philadelphia, PA 19104, USA
  • Daniel Metzger
    Institut de Génétique et de Biologie Moléculaire et Cellulaire, CNRS/INSERM/ULP, Collège de France, BP 163, 67404 Illkirch Cedex, France
  • Pierre Chambon
    Institut de Génétique et de Biologie Moléculaire et Cellulaire, CNRS/INSERM/ULP, Collège de France, BP 163, 67404 Illkirch Cedex, France
  • Karen M. Lyons
    Departments of Molecular, Cell and Developmental Biology, Orthopaedic Surgery,and Biological Chemistry, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA
  • Yuji Mishina
    Laboratory of Reproductive and Developmental Toxicology, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA
  • John T. Seykora
    Department of Dermatology, University of Pennsylvania Medical School,Philadelphia, PA 19104, USA
  • E. Bryan Crenshaw
    Center for Childhood Communication, Abramson Research Center, The Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA
  • Sarah E. Millar
    Department of Dermatology, University of Pennsylvania Medical School,Philadelphia, PA 19104, USA

説明

<jats:p>Bone morphogenetic protein (BMP) signaling is thought to perform multiple functions in the regulation of skin appendage morphogenesis and the postnatal growth of hair follicles. However, definitive genetic evidence for these roles has been lacking. Here, we show that Cre-mediated mutation of the gene encoding BMP receptor 1A in the surface epithelium and its derivatives causes arrest of tooth morphogenesis and lack of external hair. The hair shaft and hair follicle inner root sheath (IRS) fail to differentiate, and expression of the known transcriptional regulators of follicular differentiation Msx1,Msx2, Foxn1 and Gata3 is markedly downregulated or absent in mutant follicles. Lef1 expression is maintained, but nuclearβ-catenin is absent from the epithelium of severely affected mutant follicles, indicating that activation of the WNT pathway lies downstream of BMPR1A signaling in postnatal follicles. Mutant hair follicles fail to undergo programmed regression, and instead continue to proliferate, producing follicular cysts and matricomas. These results provide definitive genetic evidence that epithelial Bmpr1a is required for completion of tooth morphogenesis, and regulates terminal differentiation and proliferation in postnatal hair follicles.</jats:p>

収録刊行物

  • Development

    Development 131 (10), 2257-2268, 2004-05-15

    The Company of Biologists

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