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- Kurt W. Kohn
- Laboratory of Molecular Pharmacology, Division of Basic Sciences, National Cancer Institute, Bethesda, Maryland 20892
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- David Botstein
- editor
この論文をさがす
説明
<jats:p>Eventually to understand the integrated function of the cell cycle regulatory network, we must organize the known interactions in the form of a diagram, map, and/or database. A diagram convention was designed capable of unambiguous representation of networks containing multiprotein complexes, protein modifications, and enzymes that are substrates of other enzymes. To facilitate linkage to a database, each molecular species is symbolically represented only once in each diagram. Molecular species can be located on the map by means of indexed grid coordinates. Each interaction is referenced to an annotation list where pertinent information and references can be found. Parts of the network are grouped into functional subsystems. The map shows how multiprotein complexes could assemble and function at gene promoter sites and at sites of DNA damage. It also portrays the richness of connections between the p53-Mdm2 subsystem and other parts of the network.</jats:p>
収録刊行物
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- Molecular Biology of the Cell
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Molecular Biology of the Cell 10 (8), 2703-2734, 1999-08
American Society for Cell Biology (ASCB)
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詳細情報 詳細情報について
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- CRID
- 1360574095459643776
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- ISSN
- 19394586
- 10591524
- http://id.crossref.org/issn/10591524
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- データソース種別
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- Crossref