Critical Issues and Optimized Practices in Quantification of Protein Abundance Level to Determine Interindividual Variability in DMET Proteins by LC‐MS/MS Proteomics
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- Deepak Kumar Bhatt
- Department of Pharmaceutics University of Washington Seattle Washington USA
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- Bhagwat Prasad
- Department of Pharmaceutics University of Washington Seattle Washington USA
Description
<jats:p>Protein quantification data on drug metabolizing enzymes and transporters (collectively referred as DMET proteins) in human tissues are useful in predicting interindividual variability in drug disposition. While targeted proteomics is an emerging technique for quantification of DMET proteins, the methodology involves significant technical challenges especially when multiple samples are analyzed in a single study over a long period of time. Therefore, it is important to thoroughly address the critical variables that could affect DMET protein quantification.</jats:p>
Journal
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- Clinical Pharmacology & Therapeutics
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Clinical Pharmacology & Therapeutics 103 (4), 619-630, 2017-09-25
Wiley
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Details 詳細情報について
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- CRID
- 1360574095618805120
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- DOI
- 10.1002/cpt.819
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- ISSN
- 15326535
- 00099236
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- Data Source
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- Crossref