Leptin in Immunology

DOI PDF 4 Citations
  • Giuseppe Matarese
    *Gruppo di ImmunoEndocrinologia, Istituto di Endocrinologia e Oncologia Sperimenttale, Consiglio Nazionale delle Ricerche (IEOS-CNR), Napoli, Italy;
  • Stergios Moschos
    †Department of Medicine, Division of Hematology/Oncology, Pittsburgh Cancer Institute, Pittsburgh, PA 15232; and
  • Christos S. Mantzoros
    ‡Department of Internal Medicine, Division of Endocrinology, Diabetes and Metabolism, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215

Abstract

<jats:title>Abstract</jats:title><jats:p>Leptin is an adipokine which conveys information on energy availability. In humans, leptin influences energy homeostasis and regulates neuroendocrine function primarily in states of energy deficiency. As a cytokine, leptin also affects thymic homeostasis and, similar to other proinflammatory cytokines, leptin promotes Th1 cell differentiation and cytokine production. We review herein recent advances on the role of leptin in the pathophysiology of immune responses.</jats:p>

Journal

  • The Journal of Immunology

    The Journal of Immunology 174 (6), 3137-3142, 2005-03-15

    The American Association of Immunologists

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