Biologically active quinoline and quinazoline alkaloids part I
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- Xiao‐Fei Shang
- School of Pharmacy Lanzhou University Lanzhou P.R. China
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- Susan L. Morris‐Natschke
- Natural Products Research Laboratories, UNC Eshelman School of Pharmacy University of North Carolina Chapel Hill North Carolina
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- Ying‐Qian Liu
- School of Pharmacy Lanzhou University Lanzhou P.R. China
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- Xiao Guo
- Key Laboratory of Veterinary Pharmaceutical Development of Ministry of Agriculture, Lanzhou Institute of Husbandry and Pharmaceutical Sciences Chinese Academy of Agricultural Sciences Lanzhou P.R. China
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- Xiao‐Shan Xu
- School of Pharmacy Lanzhou University Lanzhou P.R. China
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- Masuo Goto
- Natural Products Research Laboratories, UNC Eshelman School of Pharmacy University of North Carolina Chapel Hill North Carolina
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- Jun‐Cai Li
- School of Pharmacy Lanzhou University Lanzhou P.R. China
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- Guan‐Zhou Yang
- School of Pharmacy Lanzhou University Lanzhou P.R. China
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- Kuo‐Hsiung Lee
- Natural Products Research Laboratories, UNC Eshelman School of Pharmacy University of North Carolina Chapel Hill North Carolina
Abstract
<jats:title>Abstract</jats:title><jats:p>Quinoline and quinazoline alkaloids, two important classes of <jats:italic>N</jats:italic>‐based heterocyclic compounds, have attracted tremendous attention from researchers worldwide since the 19th century. Over the past 200 years, many compounds from these two classes were isolated from natural sources, and most of them and their modified analogs possess significant bioactivities. Quinine and camptothecin are two of the most famous and important quinoline alkaloids, and their discoveries opened new areas in antimalarial and anticancer drug development, respectively. In this review, we survey the literature on bioactive alkaloids from these two classes and highlight research achievements prior to the year 2008 (Part I). Over 200 molecules with a broad range of bioactivities, including antitumor, antimalarial, antibacterial and antifungal, antiparasitic and insecticidal, antiviral, antiplatelet, anti‐inflammatory, herbicidal, antioxidant and other activities, were reviewed. This survey should provide new clues or possibilities for the discovery of new and better drugs from the original naturally occurring quinoline and quinazoline alkaloids.</jats:p>
Journal
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- Medicinal Research Reviews
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Medicinal Research Reviews 38 (3), 775-828, 2017-09-13
Wiley
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Details 詳細情報について
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- CRID
- 1360574095740601856
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- ISSN
- 10981128
- 01986325
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- Data Source
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- Crossref