Reduced Urine Kallikrein Excretion and Antikaliuresis by Chlorazanil in Rats
書誌事項
- 公開日
- 1981-09
- 権利情報
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- http://onlinelibrary.wiley.com/termsAndConditions#vor
- DOI
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- 10.1111/j.1600-0773.1981.tb00895.x
- 公開者
- Wiley
この論文をさがす
説明
<jats:p><jats:bold>Abstract:</jats:bold>In normal conscious female Sprague‐Dawley rats chlorazanil (3 mg/kg intraperitoneally) reduced urine kallikrein excretion by approximately 80%. Thus, urine kininogenase activity decreased from 54±5 U/kg/3 hrs to 10±2 U/kg/3 hrs and urine TAMe‐esterase activity decreased from 34±1.5 mEU/kg/3 hrs to 7.4±1.0 mEU/kg/3 hrs. In addition kidney kallikrein content decreased by approximately 50% from 0.76±0.03 U/kidney to 0.40±0.07 U/kidney at three hours post treatment. Chlorazanil (3 mg/kg intraperitoneally) increased urine sodium excretion from 0.48±0.04 mmol/kg/3 hrs to 2.48±0.98 mmol/kg/3 hrs and decreased the potassium excretion from 1.06±0.45 mmol/kg/3 hrs to 0.29±0.09 mmol/kg/3 hrs. Comparable antikaliuretic doses of amiloride (5 mg/kg intraperitoneally) or triamterene (10 mg/kg orally) did not change urine kallikrein excretion. It is suggested that chlorazanil inhibits kidney kallikrein synthesis perhaps by an innate antimineralocorticoid‐like effect.</jats:p>
収録刊行物
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- Acta Pharmacologica et Toxicologica
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Acta Pharmacologica et Toxicologica 49 (3), 210-214, 1981-09
Wiley